Comparison of Needling and Microneedling Plus Phototherapy in Localized Vitiligo Patients

Last updated: August 25, 2025
Sponsor: Khyber Teaching Hospital
Overall Status: Active - Recruiting

Phase

4

Condition

Vitiligo

Treatment

Microneedling + NBUVB

Needling + NBUVB

Clinical Study ID

NCT06991972
187/DME/KMC
  • Ages 15-60
  • All Genders

Study Summary

This randomized controlled trial aims to compare the efficacy of needling versus microneedling, both followed by narrowband UVB therapy, in achieving repigmentation in patients with localized stable non-segmental vitiligo.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Both male and female

  • Age 15-60 years

  • Patients having vitiligo for more than 1 year

Exclusion

Exclusion Criteria:

  • Patients with tendency of keloid formation or hypertrophic scarring

  • Patients with any bleeding disorder, coagulation defect or using anti platelets

  • Any local infection at the treatment site

  • Patients who had received systemic therapy in last 6 months

Study Design

Total Participants: 80
Treatment Group(s): 2
Primary Treatment: Microneedling + NBUVB
Phase: 4
Study Start date:
March 01, 2025
Estimated Completion Date:
August 31, 2025

Study Description

The study will enroll 80 patients aged 15-60 years with localized stable vitiligo. Participants will be randomized into two groups: one receiving needling and the other microneedling, each followed by NBUVB therapy. The primary outcome is the percentage of repigmentation at 12 weeks, assessed through digital planimetry and standardized clinical photography. Secondary outcomes include adverse effects such as erythema, post-inflammatory hyperpigmentation, infection, and scarring.

Connect with a study center

  • Khyber Teaching Hospital

    Peshawar, Khyber Pakhtunkhwa 25000
    Pakistan

    Site Not Available

  • Khyber Teaching Hospital

    Peshawar 1168197, Khyber Pakhtunkhwa 1168873 25000
    Pakistan

    Active - Recruiting

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