A Study to Learn About the Study Medicine Called PF-07328948 in Adults With Heart Failure (BRANCH-HF)

This study is seeking participants who are:

Key Inclusion Criteria include:

• aged 18 years to < 80 years

• clinically confirmed to have a diagnosis of heart failure for at least 3 months

• New York Heart Association Class II-IV symptoms

• left ventricular ejection fraction greater than 40%

• Kansas City Cardiomyopathy Questionnaire-23 Total Symptom Score < 85

• Six-minute walking distance greater than 75 meters

Key Exclusion Criteria include:

• Type 1 diabetes mellitus, liver cirrhosis or any condition that can possibly affect how the medicine is absorbed into the body.

• Major surgery scheduled for the duration of the study, affecting walking ability in the opinion of the study doctor.

• History of heart transplantation, or currently listed for a heart transplant, or current planned use of IV vasodilators and/ or inotropes

• Prior intolerance/known hypersensitivity to an SGLT2 inhibitor or contraindication to an SGLT2 inhibitor