Dexamethasone Palmitate for PONV After Minimally Invasive Endoscopic Surgery

Last updated: June 23, 2025
Sponsor: Beijing Tiantan Hospital
Overall Status: Active - Recruiting

Phase

N/A

Condition

Lactose Intolerance

Vomiting

Stomach Discomfort

Treatment

Dexamethasone

Dexamethasone palmitate

Clinical Study ID

NCT06981754
KY2025-041-02-01
  • Ages 18-65
  • All Genders

Study Summary

Dexamethasone is almost one of the most commonly used drugs for postoperative nausea and vomiting (PONV) prevention. However, PONV is still a complex problem to be solved; for example, even with preoperative dexamethasone administration, 14.0-26.3% of patients undergoing minimally invasive endoscopic procedures still experience PONV within 24 hours postoperatively. Compared to dexamethasone, dexamethasone palmitate has a long-lasting anti-inflammatory effect, 2-5 times that of traditional water-soluble dexamethasone, with fewer adverse effects. This trial aims to assess the effect and safety of preoperative dexamethasone palmitate on PONV after surgery.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Aged 18 to 65 years;

  • Providing written informed consent;

  • Perform elective minimally invasive endoscopic surgery (laparoscopic surgery,thoracoscopic surgery) undergoing general anesthesia.

Exclusion

Exclusion Criteria:

  • Known to be allergic to dexamethasone;

  • Any systemic glucocorticoids within 3 months before trial entry;

  • History of severe heart disease, liver/kidney failure, or systemic rheumaticdiseases (rheumatoid arthritis, ankylosing spondylitis, systemic lupuserythematosus, et al);

  • Cognitive impairment or severe mental illness;

  • Uncontrolled diabetes or infectious diseases;

  • Pregnancy or breastfeeding.

Study Design

Total Participants: 588
Treatment Group(s): 2
Primary Treatment: Dexamethasone
Phase:
Study Start date:
June 17, 2025
Estimated Completion Date:
December 31, 2026

Connect with a study center

  • Beijing Tiantan Hospital

    Beijing, Beijing 100070
    China

    Active - Recruiting

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