Effects of Fibres Combined With Probiotics on Uric Acid in an ex Vivo Fermentation Model

Inclusion Criteria:

1. Signed informed consent prior to any study-related procedures

2. Age 18-80 years old

3. BMI range 18.5-35 kg/m2

4. Blood uric acid above 0.36 mmol/L (6 mg/dl)

5. Willing to abstain from regular consumption of probiotic supplements or foodproducts containing probiotic bacteria (including fermented food and beverages),until collection of faecal material

6. Willing to abstain from regular consumption of supplements and medications known toalter gastrointestinal function or inflammatory status during the study, untilcollection of faecal material

Exclusion Criteria:

1. Diagnosis of type 1 and/or type 2 diabetes

2. Diagnosed inflammatory bowel disease (IBD)

3. Current diagnosis of psychiatric disease/s or syndromes

4. Current diagnosis of neurodegenerative disease

5. Current pregnancy or breastfeeding

6. History of complicated gastrointestinal surgery

7. Systemic use of antibiotics and/or steroid medication in the last 4 months prior toinclusion

8. Regular use of any non-steroidal anti-inflammatory drug (NSAID) for the last 2months

9. Consumption of any NSAID within 3 days of sample collection

10. Current (or within the last 4 weeks prior to study start) use of probioticsupplementation

11. Any condition or intake of medication which could substantially interfere with theoutcome of the study, as decided by the principal investigator's discretion

12. After being included in the study and until collection of faecal material, startingany medication or treatment that could potentially influence the study participationand/or study analysis