A Study of ATTR-01 in Participants With Select Epithelial Solid Tumours

Inclusion Criteria:

• Consenting male and female adults (18 years of age) with select solid epithelialtumour indications known to have high frequency (75 percent) of αvβ6 integrinreceptor expression as detailed in the applicable SP.

• Received and failed/intolerant of Standard of Care (SoC) therapy where eligible (notincluding neoadjuvant).

• Tumour lesion (not previously irradiated), suitable for safe pre- and post-treatmentbiopsies.

• Measurable disease by Response Evaluation Criteria in Solid Tumours (RECIST) Version 1.1.

• Eastern Cooperative Oncology Group (ECOG) Performance Status (PS) of 0 or 1.

• Minimum life expectancy anticipated to be greater than three months

• Willing to undertake appropriate measures of hygiene to prevent any spread of virusand protection of vulnerable individuals.

• Adequate organ function.

• Compliant with requirements for prior treatment washout and contraceptive measuresapplicable to genetically modified organisms (GMOs) and cancer therapies

• Prior immune checkpoint antibody therapies as single agents or in combination withother anti-cancer agents is permissible.

Exclusion Criteria:

• Significant degree of fibrotic disease, including autoimmune diseases (e.g. systemiclupus, rheumatoid arthritis) or idiopathic and occupation-related pulmonaryfibrosis.

• Known prior history of intolerance to anti-programmed cell death protein 1 (PD-1)and/or anti-PD-L1 immunotherapy due to toxicity.

• Has any of the comorbid conditions listed in the detailed protocol exclusioncriteria.