A Study of Orforglipron (LY3502970) in Participants With Obesity or Overweight and Type 2 Diabetes

Last updated: June 23, 2025
Sponsor: Eli Lilly and Company
Overall Status: Active - Recruiting

Phase

3

Condition

Diabetes Prevention

Diabetes And Hypertension

Diabetes Mellitus, Type 2

Treatment

Placebo

Orforglipron

Clinical Study ID

NCT06972472
27362
J2A-MC-GZP2
2025-521098-14-00
J2A-MC-GZPO
  • Ages > 18
  • All Genders

Study Summary

The main purpose of this study is to see how orforglipron, compared with placebo, helps improve glycemic control in participants with obesity or with overweight and type 2 diabetes. This trial is part of the master protocol study J2A-MC-GZPO.

Participation in the study will last about 18 months.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Have body mass index (BMI) ≥25 kilograms per square meter (kg/m2) at screening

  • Have type 2 diabetes

  • Have hemoglobin A1c (HbA1c) ≥7% and ≤10% at screening

  • Have a history of at least one unsuccessful dietary effort to lose body weight

Exclusion

Exclusion Criteria:

  • Have type 1 diabetes

  • Have an unstable body weight within 90 days prior to screening

  • Have New York Heart Association functional classification IV congestive heartfailure or an acute cardiovascular condition within 90 days prior to screening

  • Have acute or chronic hepatitis or pancreatitis

  • Are taking other medications or alternative remedies to manage weight loss

Study Design

Total Participants: 600
Treatment Group(s): 2
Primary Treatment: Placebo
Phase: 3
Study Start date:
May 19, 2025
Estimated Completion Date:
August 31, 2027

Connect with a study center

  • CARE - Centro de Alergia y Enfermedades Respiratorias

    Ciudad Autónoma de Buenos Aires, Buenos Aires 1414
    Argentina

    Site Not Available

  • CIPREC

    Buenos Aires, Ciudad Autónoma De Buenos Aires C1119ACN
    Argentina

    Site Not Available

  • Centro Médico Viamonte

    Buenos Aires, Ciudad Autónoma De Buenos Aires C1120AAC
    Argentina

    Site Not Available

  • Instituto Centenario

    Caba, Ciudad Autónoma De Buenos Aires 1204
    Argentina

    Site Not Available

  • Instituto Médico Catamarca IMEC

    Rosario, Santa Fe 2000
    Argentina

    Site Not Available

  • Centro de Diagnóstico y Rehabilitación (CEDIR)

    Santa Fe, 3000
    Argentina

    Site Not Available

  • The Second People's Hospital of Hefei

    Hefei, Anhui 230011
    China

    Site Not Available

  • Peking University Third Hospital

    Beijing, Beijing 100091
    China

    Site Not Available

  • Xuanwu Hospital Capital Medical University

    Beijing, Beijing 100053
    China

    Site Not Available

  • The Second Affiliated Hospital Chongqing Medical University

    Chongqing, Chongqing 400010
    China

    Site Not Available

  • Zhujiang Hospital

    Guangzhou, Guangdong 510280
    China

    Site Not Available

  • The Fourth Affiliated Hospital of Harbin Medical University

    Harbin, Heilongjiang 150001
    China

    Site Not Available

  • The First Affiliated Hospital of Henan University of Science &Technology

    Luoyang Shi, Henan 471003
    China

    Site Not Available

  • The Second Affiliated Hospital of Nanjing Medical University

    Nanjing, Jiangsu 210011
    China

    Site Not Available

  • Zhongda Hospital Southeast University

    Nanjing, Jiangsu 210009
    China

    Site Not Available

  • Jinan Central Hospital

    Jinan, Shandong 250013
    China

    Site Not Available

  • Sichuan Provincial People's Hospital

    Chengdu, Sichuan 610072
    China

    Site Not Available

  • The Second Hospital of Tianjin Medical University

    Tianjin, Tianjin 300211
    China

    Site Not Available

  • MUDr. Alena Vachova

    Ceske Budejovice, Jihočeský Kraj 37011
    Czechia

    Site Not Available

  • VASOMED Clinic

    Ostrava, Moravskoslezský Kraj 710 00
    Czechia

    Site Not Available

  • Milan Kvapil s.r.o., Diabetologicka ambulance

    Praha, Praha 4 14900
    Czechia

    Site Not Available

  • Medical Plus

    Uherske Hradiste, Zlínský Kraj 686 01
    Czechia

    Site Not Available

  • Nemocnice Cesky Krumlov

    Český Krumlov, 381 01
    Czechia

    Site Not Available

  • Medicover Neuroendokrinologie

    Munich, Bayern 81667
    Germany

    Site Not Available

  • InnoDiab Forschung Gmbh

    Essen, Nordrhein-Westfalen 45136
    Germany

    Site Not Available

  • Medizentrum Essen Borbeck

    Essen, Nordrhein-Westfalen 45355
    Germany

    Site Not Available

  • AmBeNet GmbH

    Leipzig, Sachsen 04107
    Germany

    Site Not Available

  • Gemeinschaftspraxis Dr. Taeschner/Dr. Bonigut

    Leipzig, Sachsen 04249
    Germany

    Site Not Available

  • RED-Institut GmbH

    Oldenburg, Schleswig-Holstein 23758
    Germany

    Site Not Available

  • Diabetes Zentrum Wilhelmsburg

    Hamburg, 21109
    Germany

    Site Not Available

  • Apollo Excelcare Hospital

    Guwahati, Assam 781033
    India

    Site Not Available

  • Sir Ganga Ram Hospital

    New Delhi, Delhi 110060
    India

    Site Not Available

  • Karnataka Institute of Medical Sciences

    Hubli, Karnataka 580021
    India

    Site Not Available

  • Chellaram Diabetes Institute

    Pune, Maharashtra 411021
    India

    Site Not Available

  • All India Institute of Medical Sciences

    Bhubaneswar, Odisha 751019
    India

    Site Not Available

  • Diabetes Research Center

    Hyderabad, Telangana 500082
    India

    Site Not Available

  • All India Institute of Medical Sciences - Rishikesh

    Rishikesh, Uttarakhand 249203
    India

    Site Not Available

  • Tokuyama Clinic

    Mihama-ku,Chiba City, Chiba 261-0004
    Japan

    Site Not Available

  • Hasegawa Medical Clinic

    Chitose, Hokkaido 066-0032
    Japan

    Site Not Available

  • Tsuchiura Medical & Health Care Center

    Tsuchiura, Ibaraki 300-0012
    Japan

    Site Not Available

  • Noritake Clinic

    Ushiku, Ibaraki 300-1207
    Japan

    Site Not Available

  • Olive Takamatsu Medical Clinic

    Takamatsu, Kagawa 760-0076
    Japan

    Site Not Available

  • Medical Corporation Yuga Tsuruma Kaneshiro Diabetes Clinic

    Yamato-shi, Kanagawa 242-0004
    Japan

    Site Not Available

  • Yokohama Minoru Clinic

    Yokohama, Kanagawa 232-0064
    Japan

    Site Not Available

  • Medical Corporation Heishinkai OCROM Clinic

    Suita-shi, Osaka 565-0853
    Japan

    Site Not Available

  • Fukuwa Clinic

    Chuo-ku, Tokyo 104-0031
    Japan

    Site Not Available

  • The Institute of Medical Science, Asahi Life Foundation

    Chuo-ku, Tokyo 103-0002
    Japan

    Site Not Available

  • Tokyo-Eki Center-building Clinic

    Chuo-ku, Tokyo 103-0027
    Japan

    Site Not Available

  • Medical Corporation Heishinkai ToCROM Clinic

    Shinjuku-ku, Tokyo 160-0008
    Japan

    Site Not Available

  • Shimokitazawa Tomo Clinic

    Tokyo, 155-0031
    Japan

    Site Not Available

  • Endocrinologia Especializada

    Mexico, Distrito Federal 11700
    Mexico

    Site Not Available

  • RM Pharma Specialists - Unidad Especializada en Datos

    Mexico City, Distrito Federal 03100
    Mexico

    Site Not Available

  • Diseno y Planeacion en Investigacion Medica - Guadalajara - Calle Amado Nervo

    Guadalajara, Jalisco 44600
    Mexico

    Site Not Available

  • Centro Medico Zambrano Hellion

    San Pedro Garza Garcia, Nuevo León 66278
    Mexico

    Site Not Available

  • Medical Care and Research SA de CV

    Merida, Yucatán 97070
    Mexico

    Site Not Available

  • Kohler & Milstein Research S.A. De C.V.

    Mérida, Yucatán 97070
    Mexico

    Site Not Available

  • Enclifar Ensayos Clínicos Farmacológicos Sc

    Chihuahua, 31110
    Mexico

    Site Not Available

  • Puerto Rico Health and Wellness Institute

    Dorado, 00646
    Puerto Rico

    Site Not Available

  • Isis Clinical Research Center

    Guaynabo, 00968
    Puerto Rico

    Site Not Available

  • Novak Clinical Research - Tucson - North La Cholla Boulevard

    Tucson, Arizona 85741
    United States

    Site Not Available

  • Norcal Endocrinology & Internal Medicine

    San Ramon, California 94583
    United States

    Site Not Available

  • Southern California Clinical Research

    Santa Ana, California 92701
    United States

    Site Not Available

  • Care Access - Thousand Oaks

    Thousand Oaks, California 91360
    United States

    Site Not Available

  • Accel Research Sites - DeLand Clinical Research Unit

    DeLand, Florida 32720
    United States

    Active - Recruiting

  • Innovation Medical Research Center - Fort Lauderdale

    Fort Lauderdale, Florida 33316
    United States

    Site Not Available

  • Encore Medical Research

    Hollywood, Florida 33024
    United States

    Active - Recruiting

  • West Orange Endocrinology P.A.

    Ocoee, Florida 34761
    United States

    Active - Recruiting

  • Care Access - Tampa

    Tampa, Florida 33625
    United States

    Active - Recruiting

  • Accel Research Sites - NeuroStudies Clinical Research Unit

    Decatur, Georgia 30030
    United States

    Active - Recruiting

  • Care Access - Decatur

    Decatur, Georgia 30030
    United States

    Site Not Available

  • Javara - Privia Medical Group Georgia - Savannah

    Savannah, Georgia 31406
    United States

    Site Not Available

  • North Georgia Clinical Research

    Woodstock, Georgia 30189
    United States

    Active - Recruiting

  • Solaris Clinical Research

    Meridian, Idaho 83646
    United States

    Site Not Available

  • Care Access - New Iberia

    New Iberia, Louisiana 70560
    United States

    Active - Recruiting

  • Endocrine and Metabolic Consultants

    Rockville, Maryland 20852
    United States

    Site Not Available

  • Javara - Privia Medical Group - Silver Spring

    Silver Spring, Maryland 20901
    United States

    Site Not Available

  • Boeson Research MSO

    Missoula, Montana 59804
    United States

    Site Not Available

  • Javara - Nevada Health Centers - Carson City

    Carson City, Nevada 89706
    United States

    Site Not Available

  • The Machuca Foundation

    Las Vegas, Nevada 89101
    United States

    Site Not Available

  • University of North Carolina Medical Center

    Chapel Hill, North Carolina 27514
    United States

    Site Not Available

  • Javara - Tryon Medical Partners

    Charlotte, North Carolina 28210
    United States

    Site Not Available

  • Care Access - Fayetteville

    Fayetteville, North Carolina 28314
    United States

    Site Not Available

  • The Corvallis Clinic, P.C.

    Corvallis, Oregon 97330
    United States

    Site Not Available

  • Clinical Research of Philadelphia

    Philadelphia, Pennsylvania 19114
    United States

    Site Not Available

  • Frontier Clinical Research, LLC

    Smithfield, Pennsylvania 15478
    United States

    Site Not Available

  • Velocity Clinical Research, Dallas

    Dallas, Texas 75230
    United States

    Active - Recruiting

  • Biopharma Informatic, LLC

    Houston, Texas 77043
    United States

    Active - Recruiting

  • Texas Valley Clinical Research (TVCR) - Mission

    Mission, Texas 78572
    United States

    Active - Recruiting

  • Consano Clinical Research, LLC

    Shavano Park, Texas 78231
    United States

    Active - Recruiting

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