A Long-Term Safety and Efficacy Study of Verekitug (UPB-101) in Adult Participants With Severe Asthma (VALOUR)

Inclusion Criteria:

1. Completion of the VALIANT study (UPB-CP-04 [NCT06196879]) per protocol.

2. Participant has signed, dated, and received a copy of the Institutional Review Board (IRB)/Independent Ethics Committee (IEC)-approved written informed consent form (ICF) for the LTE study.

3. Contraceptive use by participants must be consistent with local regulationsregarding the methods of contraception for those participating in clinical studies.

Exclusion Criteria:

1. Abnormal medical history, physical finding, or safety finding that in the opinion ofthe Investigator may obscure the study data or interfere with the participant'ssafety.

2. Any clinical laboratory test result outside of the reference ranges considered bythe Investigator as clinically significant and that may obscure the study data orinterfere with the participant's safety.

3. Participant with a history or evidence of a clinically significant pulmonarycondition (other than asthma), including significant restrictive findings onpulmonary function testing, chronic bronchitis, emphysema, bronchiectasis, pulmonaryfibrosis, or any other related condition that may obscure the study data (e.g.,gastroesophageal reflux and vocal cord paralysis/dysfunction).

4. Pregnant or breastfeeding or planning to become pregnant or breastfeed during thestudy or unwilling to use adequate birth control, if of reproductive potential andsexually active.

5. Participants with significant protocol deviations in VALIANT, assessed at thediscretion of the Sponsor.

6. Participant is unreliable, incapable of adhering to the protocol and visit scheduleaccording to the judgment of the Investigator or has any disorder that maycompromise their ability to give informed consent.