Microplastics and Nanoplastics (MNPs) in Patients With ST-elevation Myocardial Infarction (STEMI)

Last updated: May 1, 2025
Sponsor: Azienda Ospedaliera "Sant'Andrea"
Overall Status: Active - Recruiting

Phase

N/A

Condition

Angina

Heart Attack (Myocardial Infarction)

Congestive Heart Failure

Treatment

N/A

Clinical Study ID

NCT06965023
0379/2025
  • Ages > 18
  • All Genders

Study Summary

Air pollution and microplastics pose major public health threats. Emerging data have shown that micro- and nanoplastics (MNPs) are ubiquitous environmental pollutants accumulating in human tissues, triggering inflammation and prothrombotic state. This study will investigate the presence and burden of MNPs within coronary thrombi/thromboaspirate of patients presenting with ST segment elevation acute myocardial infarction (STEMI) undergoing primary percutaneous coronary intervention and their association with cardiac damage, plaque vulnerability, microvascular obstruction, and cardiovascular events. Plaque vulnerability will be explored by optical coherence tomography, while microvascular obstruction will be assessed by bolus thermodilution and cardiac magnetic resonance. Participants will be followed up for 1-year to evaluate whether the presence and the burden of MNPs will be associated with a higher incidence of the cardiovascular events.

Eligibility Criteria

Inclusion

Inclusion Criteria:

All the following inclusion criteria should be fulfilled:

  1. Age > 18 years old;

  2. STEMI undergoing urgent invasive coronary angiography;

  3. Acute thrombotic coronary occlusion/sub-occlusion (TIMI 0/1);

  4. Clinical indication to thromboaspiration;

  5. Able to give informed consent.

Exclusion

Exclusion Criteria:

  1. Contraindications to percutaneous coronary intervention;

  2. Hemodynamic instability or cardiogenic shock;

  3. End-stage chronic kidney disease;

  4. Life expectancy < 1 year due to non-cardiac pathology.

Study Design

Total Participants: 130
Study Start date:
April 22, 2025
Estimated Completion Date:
December 31, 2027

Connect with a study center

  • Sant'Andrea University Hospital

    Roma, Rome 00189
    Italy

    Active - Recruiting

  • Department of Environmental Biological and Pharmaceutical Sciences and Technologies, University of Campania "Luigi Vanvitelli

    Caserta,
    Italy

    Site Not Available

  • Division of Cardiology, A.O.R.N. "Sant'Anna e San Sebastiano", Caserta, Italy.

    Caserta,
    Italy

    Site Not Available

  • Cardiovascular Department, A.O.U. Policlinico "G. Rodolico - San Marco", University of Catania, Catania, Italy.

    Catania,
    Italy

    Site Not Available

  • Azienda Ospedaliero Universitaria di Ferrara, Cona, Italy

    Ferrara,
    Italy

    Site Not Available

  • Cardiovascular Division, Morgagni-Pierantoni University Hospital, Forlì, Italy.

    Forlì,
    Italy

    Site Not Available

  • Interventional Cardiology Unit, De Gasperis Cardio Center, Niguarda Hospital, Milan, Italy.

    Milan,
    Italy

    Site Not Available

  • Department of Advanced Medical and Surgical Sciences, University of Campania-Luigi Vanvitelli, Naples, Italy.

    Naples,
    Italy

    Site Not Available

  • Division of Cardiology, Cardiovascular and Thoracic Department, Città della Salute e della Scienza, Turin, Italy.

    Turin,
    Italy

    Site Not Available

  • Azienda Ospedaliera Integrata Verona, Italy

    Verona,
    Italy

    Active - Recruiting

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