TMS for Cognitive Decline in Aging and Preclinical AD

Inclusion Criteria:

1. Between the ages of 40-99

2. Native English speakers

3. Willing and able to consent to the protocol and undergo imaging andneuropsychological testing at the specified time points

4. Cognitively normal older adults and individuals with preclinical Alzheimer's diseasewill be included.

Exclusion Criteria:

1. History of head trauma involving loss of consciousness or alteration inconsciousness

2. Another major neurologic or psychiatric condition

3. Known presence of a structural brain lesion (e.g. tumor, cortical infarct)

4. Any contraindication to MRI, such as presence of pacemakers, aneurysm clips,artificial heart valves, ear implants, metal fragments, or foreign objects in theeyes, skin, or body

5. Longstanding premorbid history (i.e. longer than 10 years) of alcohol or substanceabuse with continuous abuse up to and including the time that the symptoms leadingto clinical presentation developed

6. Any significant systemic illness or unstable medical condition which could lead todifficulty complying with the study protocol.

7. Unwilling to return for follow-up, undergo neuropsychological testing, TMS, and MRimaging

8. History of unprovoked seizures (i.e., seizures that occur in the absence of a clearprovocation such as hyponatremia, hypoglycemia, etc.).

9. Subjects who have a first degree relative (e.g., father, mother or sibling) with aseizure disorder.

10. Subjects currently taking, or plan to take, medications which are highlyepileptogenic. These include: clozapine, high doses of bupropion (i.e., greater than 400mg daily), diphenhydramine, cyclosporine, isoniazid, imipenem, chloroquine,tramadol and theophylline.