Effect of Genetic Polymorphisms on Response to Preoperative NSAIDs in Endodontic Postoperative Pain Management

Last updated: April 22, 2025
Sponsor: Ataturk University
Overall Status: Active - Recruiting

Phase

N/A

Condition

Chronic Pain

Pain

Post-surgical Pain

Treatment

Placebo

Ibuprofen 600 mg

diclofenac sodium

Clinical Study ID

NCT06937853
B.30.2.ATA.0.01.00/297
  • Ages 18-65
  • All Genders
  • Accepts Healthy Volunteers

Study Summary

This study aims to evaluate the influence of genetic polymorphisms on the effectiveness of preoperative non-steroidal anti-inflammatory drugs (NSAIDs) in managing postoperative pain following endodontic treatment. Participants will receive standard preoperative NSAIDs before undergoing root canal therapy, and their pain responses will be assessed. Genetic analysis will be performed to investigate possible associations between drug response and individual gene variations. The study seeks to improve personalized approaches in endodontic pain management.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  1. Patients aged between 18 and 65 years

  2. Vital mandibular molar teeth diagnosed with symptomatic apical periodontitis

  3. ASA physical status classification I or II

  4. Preoperative VAS pain score greater than 50

  5. No known genetic disorders (e.g., Down syndrome, congenital insensitivity to pain)

Exclusion

Exclusion Criteria:

  1. Patients classified as ASA III or higher

  2. Pregnant women or those suspected of being pregnant

  3. Presence of root canal curvature greater than 25° (Schilder classification)

  4. Patients with generalized periodontitis

  5. Presence of periodontal pockets deeper than 3 mm in the affected tooth

  6. History of systemic disease or known allergies

  7. Patients with diagnosed psychiatric or psychological disorders

  8. Presence of swelling, sinus tract, or preoperative tenderness on palpation

  9. Patients with bruxism

  10. Presence of resorption in the affected tooth

  11. Use of analgesic or anti-inflammatory drugs within 12 hours prior to the procedure

  12. Teeth with root fractures, ankylosis, or pathological mobility

Study Design

Total Participants: 200
Treatment Group(s): 3
Primary Treatment: Placebo
Phase:
Study Start date:
May 10, 2024
Estimated Completion Date:
June 03, 2025

Connect with a study center

  • Ataturk University, Faculty of Dentistry, Department of Endodontics

    Erzurum, 25100
    Turkey

    Active - Recruiting

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