Data Collection for CV-3E AI Software Development

Inclusion Criteria:

1. 45-75 years of age

2. Choose to participate and must have signed the IRB-approved informed consentdocument.

Exclusion Criteria:

1. Colonoscopy or CT-colonography within the past 5 years that demonstrated no polyps

2. Colonoscopy within the past 4 years that demonstrated polyps that were removed.

3. Has contraindication for capsule endoscopy

4. Subject is suspected or diagnosed with familial adenomatous polyposis, hereditarynon polyposis colon cancer, or any high-risk genetic syndrome

5. Subject is suspected or diagnosed with inflammatory bowel disease such as ulcerativecolitis or Crohn's disease

6. History of incomplete colonoscopy

7. Type I or uncontrolled II Diabetes (Uncontrolled defined as HbA1C>6.4 within thepast 3 months and/or with history of constipation or gastroparesis).

8. Impaired cardiac function assessed as greater than NYHA Class II

9. History of small- or large-bowel obstructive condition

10. Known history of swallowing disorder, and/or ischemic bowel disease neuropathiesand/or radiation enteritis

11. Known history of NSAID enteropathy and stricture resulting from taking NSAIDs on aregular basis that, in the opinion of the Investigator, would put the subject atgreater risk for capsule endoscope retention

12. Known allergy to ingredients used in bowel preparation and boosters

13. Daily and/or regular narcotic use

14. Decompensated cirrhosis

15. Prior abdominal radiation therapy

16. Diagnosis of anorexia or bulimia

17. History of or suspicion of any of the following: strictures, volvulus or intestinalobstruction, or internal hernias or abdominal surgeries that the Investigatorbelieves should exclude the patient from study participation

18. Known or suspected megacolon

19. Scheduled to undergo MRI examination within 7 days after ingestion of the capsule

20. Has known slow gastric-emptying time or confirmed diagnosis of gastroparesis

21. Pregnant or nursing or of child-bearing potential and does not agree to practicemedically acceptable methods of contraception. Women of child bearing potential (WOCBP) must have a negative urine pregnancy test at screening.

22. Unable to follow or tolerate fasting, bowel preparation, and other study procedures

23. Any documented medical or psychological condition or significant concurrent illnesswhich, in the Investigator's opinion, would make it unsafe for the subject toparticipate in this research study or would affect the validity of the study results

24. Are currently enrolled in an interventional clinical study or currently enrolled inor within the last 30 days, a pharmaceutical clinical study

25. Chronic constipation as defined by <3 bowel movements per week, or the use ofroutine laxatives (other than fiber) to attain regular bowel movements