Effect of Lentils and Chickpeas on Gut Microbiome and Metabolic Health

Last updated: April 4, 2025
Sponsor: Florida State University
Overall Status: Active - Recruiting

Phase

N/A

Condition

N/A

Treatment

Goya Foods - Canned Lentils

Control

Goya Foods - Canned Chickpeas

Clinical Study ID

NCT06914375
STUDY00005525
58-3060-4-041
  • Ages 18-30
  • All Genders
  • Accepts Healthy Volunteers

Study Summary

The primary goal of this research is to evaluate the effect of daily whole-cooked chickpea and lentil consumption for 8-weeks on gut health, including microbiome-metabolome arrays and gut epithelial/barrier function, in healthy young adults.

Secondary Objectives include:

  • To examine the effect of daily whole-cooked chickpea and lentil consumption for 8-weeks on the measures of metabolic health and inflammation in healthy young adults.

  • To determine the feasibility of healthy young adults to successfully incorporate and sustain the recommended daily intake of pulses into their diets for eight consecutive weeks

Research Interventions:

Participants will be asked to consume a normal diet supplemented daily with either A) whole-cooked canned lentils, or B) whole-cooked canned chickpeas. The control condition will be instructed to consume a normal diet while restricting all pulse intake throughout the study.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Between 18 and 30 years old

  • Ability to speak and read in English

Exclusion

Exclusion Criteria:

  • Intake of antibiotics in the last 3 months

  • Intake of pre/pro/postbiotics in the last 3 months

  • Current or past (within the last 6 months) user of tobacco, marijuana, orE-cigarette products

  • Cardiovascular disease (heart failure, hypertension, hyper/dyslipidemia, pastmyocardial infarction)

  • Gastrointestinal disease (ulcerative colitis, Crohn's disease, diverticulosis,peptic ulcers, small intestinal bacterial overgrowth, fistulas, suspected or knowngastric strictures, gastritis, radiation enteritis, GI bleeding, gastric bezoar,recent GI surgery in the last 3 months, etc..),

  • Neurological disorders (multiple sclerosis, meningitis, recent stroke) or endocrinedisorders (uncontrolled thyroid disorders, growth hormone disorders, adrenal glanddisorders, uncontrolled or insulin dependent diabetes - A1C > 9%).

  • Food allergy to study foods (pulses or soy, milk, peanuts, tree nuts)

  • Regular consumption of pulses (>1 cup/wk for males; >0.5 cup/wk for females)

  • Current heavy alcohol use (≥ 15 drinks / week for men, ≥ 8 drinks / week for women)

  • Class 3 Obesity (BMI > 40 kg/m2)

  • Known to be currently pregnant (self-disclosed).

Study Design

Total Participants: 60
Treatment Group(s): 3
Primary Treatment: Goya Foods - Canned Lentils
Phase:
Study Start date:
March 28, 2025
Estimated Completion Date:
June 30, 2027

Connect with a study center

  • Florida State Univresity - The Gut Biome Lab

    Tallahassee, Florida 32306
    United States

    Active - Recruiting

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