A Study of the Blood Levels of Palovarotene in Participants With Abnormal Liver Function Compared to Healthy Adult Participants After Intake of a Single Dose

Inclusion Criteria:

• Male and female participants must be 18 to 70 years of age (inclusive) at the timeof signing informed consent.

• Body weight at least 60.0 kg with body mass index (BMI) within the range of 18.0 and 36.0 kg/m² (inclusive), at screening. BMI of >36.0 to ≤37.0 may be eligible ifparticipant has ascites scoring 3 points on the C-P criteria.

• Contraceptive use by men or women should be consistent with local regulationsregarding the methods of contraception for those participating in clinical trials

• Clinical diagnosis of chronic hepatic disease (stable for more than 3 months) with adocumented history of underlying hepatic insufficiency and no acute episodes ofillness within 30 days prior to Day -1 (admission) and no significant change indisease status (i.e. up to 1 point in the C-P classification) from screening to Day -1.

• A stable medication regimen, defined as not starting new therapy(ies) or significantchanging dosage(s) within 30 days prior to dosing.

Exclusion Criteria:

• Presence or significant history of cardiovascular, respiratory, hepatic (except forthe hepatic impairment for those concerned), renal, gastrointestinal, biliary,mucocutaneous, endocrinological, haematological or neurological disorders capable ofsignificantly altering the absorption, metabolism, or elimination of drugs,constituting a risk when taking the study intervention, or interfering with theinterpretation of data.

• Lymphoma, leukaemia or any malignancy within the past 5 years except for basal cellor squamous epithelial carcinomas of the skin that have been resected with noevidence of metastatic disease for 3 years.

• Breast cancer within the past 10 years.

• Use of any medications (prescription or over the counter), herbal tea, energy drinks (including natural stimulants), herbal products (e.g. St. John's wort, garlic, milkthistle) or supplements/supratherapeutic doses of vitamins within 14 days prior toDay 1 and through discharge, apart from those approved by the investigator and thesponsor's medical monitor. Those with hepatic impairment may take concomitantmedications

• Use of any medications that are moderate or strong inhibitors or inducers of CYP3A4

• Donation or loss (excluding volume drawn at screening or during menses) of more than 250 mL of blood or blood product within 3 months prior to screening. In addition,plan of blood donation within 8 weeks after the last PK sampling.

• Presence of hepatitis B surface antigen (HBsAg) at screening or within 3 monthsprior to the dose of study intervention.

• Positive hepatitis C antibody test result at screening or within 3 months prior tothe dose of study intervention. Note: Participants with positive hepatitis Cantibody due to prior resolved disease can be enrolled if a confirmatory negativehepatitis C ribonucleic acid (RNA) test is obtained.

• Positive hepatitis C RNA test result at screening or within 3 months prior to thedose of study intervention. Note: Test is optional and participants with negativehepatitis C antibody test are not required to also undergo hepatitis C RNA testing.

• Sensitivity to the study intervention, or components thereof (including inactiveingredients), or drug or other allergy that, in the opinion of the investigator (ormedical monitor), contraindicates participation in the study

• Evidence of relevant active disease at screening, including gastroenterological (other than hepatic cirrhosis), cardiac (e.g. myocardial infarction in the pastyear, angina or congestive heart failure), renal, respiratory, haematological,neuropsychiatric or neoplastic (basal or squamous cell skin cancer is acceptable)disease.

• Acute hepatitis B (positive for HBsAg) or acute hepatitis C (positive foranti-hepatitis C virus (HCV) for a duration of less than 6 months). Note:Participants with chronic HCV (positive for HCV RNA or anti-HCV for more than 6months) are eligible for enrolment, if stable, as assessed by the investigator.

• Primary sclerosing cholangitis or preliminary diagnosed biliary obstruction atscreening.

• Current or chronic history of liver disease. This includes (but is not limited tohepatitis virus infections), drug- or alcohol-related liver disease, non-alcoholicsteatohepatitis, autoimmune hepatitis, hemochromatosis, Wilson's disease, α-1antitrypsin deficiency, primary biliary cholangitis, primary sclerosing cholangitis,or any other liver disease considered clinically significant by the investigator.