Intertransverse Process Block for Postoperative Acute Pain After Coronary Bypass Surgery

Last updated: May 5, 2025
Sponsor: Mustafa Aydemir
Overall Status: Active - Recruiting

Phase

N/A

Condition

Acute Pain

Post-surgical Pain

Chronic Pain

Treatment

placebo saline injection

Bilateral Intertransverse Process Block (ITPB)

Clinical Study ID

NCT06908681
MSTF-KVCAGRI-2025-01
  • Ages > 18
  • All Genders

Study Summary

This prospective, randomized controlled trial aims to evaluate the effect of bilateral intertransverse process block (ITPB) on acute postoperative pain in patients undergoing coronary artery bypass grafting (CABG) via median sternotomy. Patients will be randomly assigned to receive either ITPB or placebo (saline) injection prior to surgery. Postoperative pain scores, opioid consumption, and recovery quality will be assessed during the first 24 hours following extubation.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Age ≥ 18 years

  • Elective coronary artery bypass grafting (CABG) via median sternotomy planned

  • Able to provide written informed consent

  • Able to communicate symptoms reliably with the research team

Exclusion

Exclusion Criteria:

  • Emergency CABG surgery

  • Infection or open wound at the injection site

  • Coagulopathy

  • Hepatic or renal failure

  • Reoperation cases

  • Incomplete or missing data

Study Design

Total Participants: 70
Treatment Group(s): 2
Primary Treatment: placebo saline injection
Phase:
Study Start date:
May 05, 2025
Estimated Completion Date:
September 02, 2025

Study Description

Coronary artery bypass grafting (CABG) is associated with significant postoperative pain due to sternotomy and tissue manipulation, which may impair recovery, increase opioid consumption, and prolong hospital stay. Regional anesthesia techniques are increasingly used as part of multimodal analgesia strategies to minimize opioid-related side effects. The intertransverse process block (ITPB) is a novel regional technique that targets the dorsal rami of spinal nerves and may provide effective bilateral analgesia in thoracic procedures with a favorable safety profile.

This prospective, randomized, triple-blind controlled study aims to investigate the effect of preoperative bilateral ITPB on postoperative acute pain, opioid consumption, and recovery quality in adult patients undergoing elective CABG via median sternotomy. Patients will be randomized to receive either ITPB with 0.25% bupivacaine or a placebo (saline) injection under ultrasound guidance. Postoperative outcomes, including Numeric Rating Scale (NRS) pain scores, rescue analgesic use, total opioid consumption, and Quality of Recovery-15 (QoR-15) scores, will be collected within the first 24 hours following extubation. The results of this study may support the incorporation of ITPB into routine analgesia protocols for cardiac surgery patients.

Connect with a study center

  • University of Health Sciences, Konya City Hospital

    Konya, 42080
    Turkey

    Active - Recruiting

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