Brain Activity Changes After Cognitive Behavioral Therapy for Anxiety in Autistic Youth From High-Need Communities

Last updated: June 19, 2025
Sponsor: Montclair State University
Overall Status: Active - Recruiting

Phase

N/A

Condition

Williams Syndrome

Panic Disorders

Anxiety Disorders

Treatment

Facing Your Fears (FYF) Intervention: A CBT Focused Group Treatment for Autistic Youth with Anxiety

Clinical Study ID

NCT06904508
IRB-FY23-24-3257
CDMRP-AR230226
  • Ages 8-14
  • All Genders

Study Summary

The goal of this clinical trial is to investigate neural constructs related to anxiety symptoms in response to Facing Your Fears (FYF) treatment in autistic participants with co-occurring anxiety.

Researchers will compare participants receiving immediate FYF intervention to those in the waitlist control group (receiving treatment as usual) to see if there are differences in neural constructs and anxiety symptom changes over the study period.

Participants will:

  • Complete the Facing Your Fears (FYF) intervention if assigned to the immediate treatment group

  • Continue their usual treatment during a waitlist period if assigned to the control group, followed by the opportunity to participate in FYF intervention after the waiting period ends

  • Complete assessments of neural constructs, anxiety symptoms, and other measures

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Between the ages of 8 and 14

  • Have significant deficits in reciprocal social behavior as defined by a score of 11or above on the parent-report SCQ questionnaire

  • Are verbally fluent in English, enabling them to participate in the appropriatemodules (3 or 4) of the researcher-administered ADOS-2

  • Have an estimated verbal IQ of 70 or above as determined by theresearcher-administered KBIT-2

  • Have clinically significant anxiety symptoms as defined by significant elevations oneither the parent-report SCARED questionnaire or the parent-report PRAS-ASDquestionnaire

  • Have a legal guardian who can provide consent for their child's participation aswell as their own participation in the intervention alongside their child. If thelegal guardian is unable to participate in the intervention themselves but wouldlike for their child to receive the intervention with another caregiver who liveswith the child, the legal guardian will still be the one to sign the consent form,but will provide permission for another caregiver (logged on the consent form) toparticipate in the intervention alongside the child

Exclusion

Exclusion Criteria:

  • Fail to meet any of the above inclusion criteria

  • If it is determined by the research team via parent report or direct observationthat the child has a severe medical or psychiatric impairment (e.g., psychosis,severe aggressive behavior, or other severe clinical symptoms) that require moreintensive treatment such as day treatment or hospitalization

Study Design

Total Participants: 60
Treatment Group(s): 1
Primary Treatment: Facing Your Fears (FYF) Intervention: A CBT Focused Group Treatment for Autistic Youth with Anxiety
Phase:
Study Start date:
April 30, 2025
Estimated Completion Date:
September 30, 2027

Study Description

Aims of the study:

  • How do brain activity patterns (measured by EEG) relate to anxiety symptoms in autistic youth, as reported by both the youth and their parents?

  • Will brain activity changes line up with improvements in anxiety after FYF treatment in autistic youth from underserved communities?

  • Will brain activity relate to other factors related to anxiety (e.g., a person's ability to handle uncertainty and manage emotions)?

Connect with a study center

  • Montclair State University

    Montclair, New Jersey 07043
    United States

    Active - Recruiting

  • Drexel University

    Philadelphia, Pennsylvania 19104
    United States

    Active - Recruiting

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