Disorders of gut-brain interactions (DGBI) (also known as functional gastrointestinal
disorders (FGID)) are defined as distinct combinations of chronic or recurrent
gastrointestinal symptoms, with no obvious structural or biochemical abnormalities that
explain symptomatology (Fairlieetal.,2023). DGBI symptoms are most likely generated based
on a complex interaction among factors such as microbial dysbiosis within the gut,
altered mucosal immune function, altered gut signaling (visceral hypersensitivity), and
central nervous system dysregulation of the modulation of gut signaling and motor
function (Drossman et al., 2016). Additionally, researchers have identified a
bi-directional communication pathway between the central nervous system and the
gastrointestinal (GI) tract, termed the gut-brain axis. The gut-brain axis suggests that
changes in either the central nervous system or gut can disrupt the balance of the other.
Therefore, psychosocial factors impacting the gut-brain axis increase GI symptoms and
symptom severity and affect treatment outcomes (Vivier et al., 2020), and GI symptoms
reduce psychosocial functioning in a reciprocal fashion.
The bi-directional communication system between the gut and brain is thought to play a
critical role in maintaining gastrointestinal health and homeostasis, and an imbalance in
either can have adverse consequences, often seen in conditions like IBS (Vivier et al.,
2020). This is termed the gut-brain axis. It involves a complex interaction between the
central nervous system (CNS) and the enteric nervous system (ENS), both of which regulate
gut function and are affected by psychological states. Reflexes that generate appropriate
gut responses to physiological as well as pathological afferent gut signals occur at the
level of the ENS (Peters et al., 2015). Given this intricate connection, therapeutic
approaches that target both physiological and psychological aspects may be particularly
beneficial.
Based on the Rome IV criteria, there are several categories of DGBI including 1.)
esophageal (e.g. gastroesophageal reflux disease (GERD, esophageal spasms)), 2.)
gastroduodenal (e.g. chronic gastritis, peptic ulcer disease), 3.) bowel (e.g. irritable
bowel syndrome (IBS), 4.) functional diarrhea), 5.) centrally mediated disorders of
gastrointestinal (GI) pain (e.g. functional heartburn, functional abdominal pain syndrome
(FAPS)), 6.) gallbladder and sphincter of oddie (e.g. sphincter of oddi dysfunction
(SOD), biliary dyskinesia), 7.) anorectal (e.g. functional constipation, functional fecal
incontinence), and 8.) childhood functional GI disorders (e.g. diarrhea, constipation,
abdominal pain). A recent global internet survey of 54,127 adults across 26 countries
found that 43% of people met the criteria for at least one FGID (Black et al., 2020). To
date, there have not emerged highly effective interventions for these disorders, making
it essential to explore innovative treatments. One such promising approach has been
gut-directed hypnotherapy (GDH). The current study aims to evaluate (a) whether GDH
offers symptom relief beyond the shared components of hypnotherapy and (b) the efficacy
of GDH when delivered in group-based and telehealth formats. Findings will contribute to
understanding GDH's role in DGBI management, in addition to its effectiveness in a
group-based, telehealth format.