Phase
Condition
Schizotypal Personality Disorder (Spd)
Borderline Personality Disorder
Mood Disorders
Treatment
Stress Induction
Clinical Study ID
Ages 18-45 All Genders Accepts Healthy Volunteers
Study Summary
Eligibility Criteria
Inclusion
Inclusion Criteria:
Borderline Personality Disorder (BPD) group:
Score of 38 or higher on Personality Assessment Inventory-Borderline Scale (PAI-BOR)
Participants in the BPD group will be primarily recruited from the two
DEPENd lab studies that maintain large samples of BPD participants. To ensure maximal similarity between BPD participants recruited from other DEPENd lab studies and BPD participants recruited through other recruitment sources, the investigators will use the same criteria for the BPD group in the current study as the criteria used in the other DEPENd lab studies. BPD participants in the two DEPENd lab studies from which the investigators will be recruiting must meet the following criteria:
3+ BPD symptoms, one of which must be affective instability, per clinical interview
Participants must score at least 80 on the Reynolds Intellectual Screening Test (RIST).
Health Control (HC) Group:
Score of 12 or lower on PAI-BOR
Score below 50th percentile on World Health Organization Disability AssessmentSchedule (WHODAS)
Absence of any current or lifetime psychiatric disorder, including personalitydisorders as determined by diagnostic interviews (SIDP and SCID), if the participanthad participated in the lab's other studies (IRB Nos. 20-1735 and 21-0602).
Combined Inclusion Criteria:
Ages 18-45
Provision of signed and dated informed consent form
Stated willingness to comply with all study procedures and lifestyle considerationsand availability for the duration of the study
Willingness to participate in all components of the study
Participants must be able to speak, understand and read English.
Participants must have at least 20/40 visual acuity (correct or uncorrected).
Exclusion
Exclusion Criteria:
Use of as needed antihypertensive agents within 12 hours prior to lab visit
Inability to refrain from using as needed psychotropic medications for 12 hoursprior to lab visit
History of psychotic disorder, Bipolar I disorder, autism spectrum disorder,reactive attachment disorder, pervasive developmental disorder, motor disorder, headinjury, mental retardation, neurological disorder, or current substance dependence
Family history of Bipolar I disorder in a first degree relative.
Participants are also excluded for any of the following: cardiac pacemaker, aneurysmclip, cochlear implants, pregnancy, shrapnel, history of metal fragments in eyes,neurostimulators, weight of 250 lbs. or more, or claustrophobia.
Study Design
Connect with a study center
University of North Carolina at Chapel Hill
Chapel Hill, North Carolina 27514
United StatesActive - Recruiting

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