Functional MRI During Resting State in Patients with Eating Disorders

Last updated: March 11, 2025
Sponsor: Meyer Children's Hospital IRCCS
Overall Status: Active - Recruiting

Phase

N/A

Condition

Anorexia

Vomiting

Bulimia

Treatment

structural and functional MRI

Clinical Study ID

NCT06874348
RS-FMRI-ED
  • Ages 12-40
  • Female

Study Summary

The goal of this observational study is to learn if clinical and neurophysiological characteristics dynamics may follow similar trends in a longitudinal characterization of patients with a diagnosis of an eating disorder.

The primary hypothesis is that the reversal of Functional Magnetic Resonance Imaging (fMRI) baseline alternations is positively associated with symptomatic amelioration.

The secondary hypothesis is that the degree of (f)MRI baseline alternations is positively associated with symptoms.

Participants will be asked to complete psychometric questionnaires, perform a fMRI and be recalled at 12 months for a follow-up.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Female sex

  • Age between 12 and 40 years old

  • Current diagnosis of Anorexia Nervosa or Bulimia Nervosa according to DSM-5-TR.

Exclusion

Exclusion Criteria:

  • Previous or current diagnosis of schizophrenia or bipolar disorder,

  • Acute psychosis

  • Substance abuse

  • Severe medical comorbidities (hypercapnia, severe hypertension, cardiac arrhythmia,organ failure)

  • incapacity to grant written or verbal consent

Study Design

Total Participants: 50
Treatment Group(s): 1
Primary Treatment: structural and functional MRI
Phase:
Study Start date:
October 24, 2024
Estimated Completion Date:
October 31, 2026

Connect with a study center

  • Azienda Ospedaliero-Universitaria Careggi, Firenze

    Florence,
    Italy

    Active - Recruiting

  • Meyer Children's Hospital IRCCS

    Florence,
    Italy

    Active - Recruiting

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