Phase 2b Study of EVO756 in Adults With Moderate to Severe Chronic Spontaneous Urticaria (CSU)

Inclusion Criteria:

• Confirmed CSU diagnosis for at least 3 months with an inadequate response toH1-antihistamines.

• Subjects who are taking H1-antihistamines must be on a stable regimen 4 weeks priorto Day 1 and while on study.

• Urticaria Activity Score (UAS7) equal to or greater than 16 at Day 1. UAS entriesmust be completed for a minimum of 4 out of the 7 days prior to Day 1.

Exclusion Criteria:

• Any clinically significant abnormality in laboratory evaluations, physicalexaminations, vital signs, or ECG at Screening, according to the Investigator'sdiscretion.

• Use of certain medications.

• History of diseases with urticaria or angioedema symptoms, other than CSU andsymptomatic dermographism.

• Significant medical history other than CSU, or any other condition which mightinterfere with the evaluation of CSU.