Acute Effects of Isoenergetic HIIE Vs. MICE on Key Parameters of Fat Mass Loss in Young Females with Overweight or Obesity

Last updated: March 4, 2025
Sponsor: Laboratoire des Adaptations Métaboliques à l'Exercice en conditions Physiologiques et Pathologiques
Overall Status: Active - Recruiting

Phase

N/A

Condition

Obesity

Hypertriglyceridemia

Treatment

Exercise

Clinical Study ID

NCT06868862
CAAE: 79561024.4.0000.9487
  • Ages 20-45
  • Female
  • Accepts Healthy Volunteers

Study Summary

Overweight and obesity, particularly increased total and/or abdominal fat mass (FM), are strongly linked to the development of cardiovascular diseases. Managing obesity effectively requires lifestyle and dietary modifications, including increased physical activity. Among the various exercise strategies, Moderate-Intensity Continuous Training (MICT) and High-Intensity Interval Training (HIIT) are widely recommended for reducing FM. Compared to MICT, HIIT is a time-efficient approach, often perceived as more enjoyable, and has been shown to promote greater total and abdominal fat loss in a shorter period. However, the precise mechanisms underlying this enhanced fat loss remain unclear.

This study aims to compare the acute effects of two isoenergetic exercise sessions - MICE (Moderate-Intensity Continuous Exercise) and HIIE (High-Intensity Interval Exercise) - on key physiological responses involved in fat mass loss. Specifically, we will assess plasma catecholamine levels during exercise and recovery, as well as oxygen consumption, substrate oxidation, and appetite over the 2-hour post-exercise period in young females with overweight or obesity. By elucidating the role of catecholaminergic stimulation as a potential regulator of fat mass loss, this research could provide valuable insights for optimizing exercise strategies in weight management and metabolic health.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • women with overwieght or obesity (BMI: 25-35 kg/m²)

Exclusion

Exclusion Criteria:

  • contraceptive use

  • menopause

  • irregular menstrual cycle

  • medical contraindications to intense physical activity,

  • painful joints,

  • taking ß-blocker

Study Design

Total Participants: 15
Treatment Group(s): 1
Primary Treatment: Exercise
Phase:
Study Start date:
February 01, 2025
Estimated Completion Date:
December 30, 2025

Connect with a study center

  • Laboratório de Fisiologia e Metabolismo Aplicados à Educação Física

    Sao Paulo, 475
    Brazil

    Active - Recruiting

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