Evaluation of MicroRNAs and Vitamin B12 Expression in Subjects with Neurologic Symptoms of Depression, Anxiety and Fatigue in Long COVID-19

Last updated: March 5, 2025
Sponsor: Instituto Nacional de Rehabilitacion
Overall Status: Active - Recruiting

Phase

N/A

Condition

Depression

Pain (Pediatric)

Treatment

N/A

Clinical Study ID

NCT06864156
03/24 AD 2025
  • Ages 18-65
  • All Genders
  • Accepts Healthy Volunteers

Study Summary

At the moment, the number of people with long COVID is unkown because there is still no effective diagnosis. This is why is very important to analyze the most common symptoms, which are: depression, anxiety and fatigue. This project seeks to analyze some blood components of people with long COVID, such as microRNAs and vitamin B12, in order to identify the body processes that changed after COVID-19 and thereby design better therapies and diagnostic methods focused on each of them.

The hypothesis is that the expression of miR-21, -146a and -155 will be overexpressed as well as there will be a deficiency of vitamin B12 in serum in subjects suffering from long COVID with neurological symptoms of depression, anxiety and fatigue.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Subjects with confirmed diagnosis of COVID-19 by SARS-CoV-2 infection by PCR orantigen testing.

  • With presence of neurological symptoms of depression, anxiety and fatigue associatedwith COVID-19 after three months from the first day of acute infection symptoms.

Exclusion

Exclusion Criteria:

  • Subjects who have presented symptoms of acute infection in the last twelve weeks.

  • Subjects who present diagnostic premorbid neurological alterations.

  • Subjects who do not have at least 2 doses of COVID-19 vaccine, with last applicationdate equal or older than 3 months.

Study Design

Total Participants: 20
Study Start date:
February 18, 2025
Estimated Completion Date:
July 31, 2025

Connect with a study center

  • Instituto Nacional de Rehabilitación

    Ciudad de México, 14389
    Mexico

    Active - Recruiting

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