Standardized Procedure for Intracranial Drug-Eluting Stenting in the Treatment of Intracranial Atherosclerotic Stenosis

Inclusion Criteria:

1. Males or females between 18 and 80 years of age

2. Symptomatic intracranial arteriosclerosis stenosis with reference diameter 2.25-4.00mm

3. Intracranial artery stenosis ( ≥70%) conformed by DSA

4. Those who voluntarily participate in the study and sign informed consent form

Exclusion Criteria:

1. Those who have surgery within previous 30 days or plan to perform major surgery inthe next 90 days (surgery grade 3 and above);

2. Subjects of acute hemorrhagic stroke within 3 months;

3. The baseline mRS of disabling stroke is more than 3;

4. The target vessel is severely calcified and closely related to stenosis;

5. Non-atherosclerotic diseases (e.g. arterial dissection, Moya Moya disease, vascularinflammatory lesions caused by infection, autoimmune diseases, post-irradiation,postpartum status; developmental or genetic abnormalities such as fibromusculardysplasia, sickle cell anemia, suspected vasospasm);

6. It is suspected that the ischemic event is due to embolism or arterial embolism fromthe extracranial segment (including ipsilateral chest or neck vascular occlusivedisease) or potential cardiogenic embolism (e.g. atrial fibrillation, mitralstenosis, patent foramen ovale, left ventricular thrombus, myocardial infarctionwithin 6 weeks, etc.);

7. The presence of a >50% stenosis in the main blood supply artery of the targetvessel. For example, when the lesion is located in the middle cerebral artery, theipsilateral internal carotid artery stenosis by over 50% should be excluded; whenthe lesion is located in the basilar artery, the dominant side vertebral arterystenosis >50% should be excluded;

8. There are intracranial tumors, or intracranial arteriovenous malformations;

9. Those who are allergic to heparin, aspirin, clopidogrel, contrast agents,anesthetics, and stent components;

10. Pregnant and lactating women

11. Those who are unable to complete follow-up because of mental illness, cognitive oremotional disorders;

12. Inapplicable for this study at the investigators' viewpoints.