The Norwegian Immunotherapy in Multiple Myeloma Study

Last updated: February 26, 2025
Sponsor: St. Olavs Hospital
Overall Status: Active - Recruiting

Phase

N/A

Condition

Amyloidosis

Leukemia

Multiple Myeloma

Treatment

Talquetamab

Idecabtagene vicleucel

Elranatamab

Clinical Study ID

NCT06855121
NIMMS
  • Ages > 18
  • All Genders

Study Summary

The goal of this observational study is to study the effectiveness and complications of novel immunotherapies used in the treatment of multiple myeloma in routine care in Norway. The aim is to close knowledge gaps, generate evidence for future clinical trials and contribute to future consensus on how to monitor for adverse events, and what mitigation strategies should be implemented, so that we can increase patient survival and quality-of-life.

Eligibility Criteria

Inclusion

Inclusion criteria

  • Participants age ≥ 18 years

  • Prior diagnosis of one of the following

  • Multiple myeloma as defined according to IMWG criteria

  • Primary plasma cell leukemia as defined according to IMWG consensus definition

  • AL-amyloidosis as defined according to IMWG criteria

  • Planned treatment with one of the following outside clinical trials (list to beamended based on approvals within the EU):

  • Teclistamab (Tecvayli)

  • Elranatamab (Elrexfio)

  • Talquetamab (Talvey)

  • Idecabtagene vicleucel (ide-cel/Abecma)

  • Ciltacabtagene autoleucel (cilta-cel/Carvykti)

Exclusion

Exclusion Criteria:

  • None

Study Design

Total Participants: 400
Treatment Group(s): 5
Primary Treatment: Talquetamab
Phase:
Study Start date:
January 15, 2025
Estimated Completion Date:
December 01, 2037

Connect with a study center

  • Sørlandet Hospital - Arendal

    Arendal,
    Norway

    Site Not Available

  • Haukeland University Hospital

    Bergen,
    Norway

    Site Not Available

  • Bodø Hospital

    Bodø,
    Norway

    Site Not Available

  • Bærum Hospital

    Bærum,
    Norway

    Site Not Available

  • Drammen hospital

    Drammen,
    Norway

    Site Not Available

  • Førde hospital

    Førde,
    Norway

    Site Not Available

  • Innlandet hospital trust

    Gjøvik,
    Norway

    Site Not Available

  • Haugesund hospital

    Haugesund,
    Norway

    Site Not Available

  • Sørlandet hospital

    Kristiansand,
    Norway

    Site Not Available

  • Nordmøre and Romsdal Hospital - Kristiansund

    Kristiansund,
    Norway

    Site Not Available

  • Levanger hospital

    Levanger,
    Norway

    Site Not Available

  • Nordmøre and Romsdal Hospital - Molde

    Molde,
    Norway

    Site Not Available

  • Akershus University Hospital (AHUS)

    Nordbyhagen,
    Norway

    Site Not Available

  • Diakonhjemmet hospital

    Oslo,
    Norway

    Site Not Available

  • Lovisenberg Diaconal Hospital

    Oslo,
    Norway

    Site Not Available

  • Oslo Myeloma Center, Oslo University Hospital

    Oslo,
    Norway

    Site Not Available

  • Telemark Hospital Trust

    Skien,
    Norway

    Site Not Available

  • Stavanger University hospital

    Stavanger,
    Norway

    Site Not Available

  • University hospital of North Norway

    Tromsø,
    Norway

    Site Not Available

  • St. Olavs hospital HF

    Trondheim,
    Norway

    Active - Recruiting

  • Vestfold Hospital Trust

    Tønsberg,
    Norway

    Site Not Available

  • Volda hospital

    Volda,
    Norway

    Site Not Available

  • Ålesund hospital, Department of hematology

    Ålesund,
    Norway

    Site Not Available

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