A Trial of "APL-9796'' in Adults With Pulmonary Hypertension

Inclusion Criteria:

1. Participant must be 18 to 80 years of age inclusive

2. Participants who are diagnosed with pulmonary hypertension via right heartcatheterisation (RHC), documented at any time prior to Screening.

3. WHO Functional Class II or III

4. Participant has the CardioMEMS PA Sensor implanted.

Exclusion Criteria:

1. Hospital admission related to PH within 3 months prior to Screening.

2. Major surgical procedure within 3 months prior to Screening, unless participant isassessed as completely recovered by the Investigator

3. Diagnosis of PH due to human immunodeficiency virus, portal hypertension,schistosomiasis, or uncorrected congenital heart disease

4. History of left-sided heart disease and/or clinically significant cardiac disease

5. History of uncontrolled systemic hypertension

6. eGFR ≤30 ml/min/1.73m2

7. Life expectancy of < 12 months, as assessed by the Investigator

8. Diagnosed with a malignancy within 5 years of enrolment

9. Contraindications to protocol-required imaging (MRI), diagnostic, or samplingmethods