Measurement of Intestinal Permeability in Intensive Care Patients With Single or Multiple Organ Failure

Inclusion Criteria:

Patient with single organ failure, secondary to sepsis, hospitalized in intensive care for a foreseeable duration of > 48 hours

• SAPS2 between 20 and 40 at the sixth hour after the diagnosis of organ failure.

• Consent from the patient or their trusted person.

• Affiliation to a social security system.

• Functional digestive tract and possible feeding (per os or via a nasogastric tubewhose indication was determined independently of the study's needs).

Second group of patients with multi-organ failure:

• Multi-organ failure syndrome with at least 2 organ failures, secondary to sepsis.

• SAPS2 between 60 and 80 at the sixth hour after the diagnosis of organ failure.

• Consent from the patient or their trusted person.

• Affiliation to a social security system.

• Functional digestive tract and possible feeding (conscious patient able to swallowor with a nasogastric tube whose indication was determined independently of thestudy's needs).

Exclusion Criteria:

• Pregnant and breastfeeding women;

• Minors;

• Persons under administrative and judicial supervision;

• Absence of a functional digestive tract (patient unable to swallow and absence of anasogastric tube, contraindication to enteral feeding);

• Patients with gastroparesis;

• Refusal of the patient or their trusted person;

• Patient with a SAPS2 at the sixth hour after the diagnosis of organ failure < 20 orbetween 40 and 60 or > 80.