Prevention of Postpartum Venous Thromboembolism in Women at Intermediate Risk

Inclusion Criteria:

• Women at intermediate risk of VTE during post-partum= with a 3% or more risk of VTEbased on a validated prediction model* or International guidelines (ACCP 2012).

• Age over 18 years

• Delivery between 6 hours and < 36 hours

• Written informed consent

• Definition: Intermediate risk is defined as ≥ 3%, based on risk predictionmodel developed by Sultan et al taking in account: smoking, varicose veins,obesity, comorbidities, diabetes, pre-eclampsia, post-partum hemorrhage,postpartum infection, emergency or elective section or following ACCPguidelines: one major risk factor or two minor risk factors.

Exclusion Criteria:

• Previous personal history of VTE

• LMWH started during antenatal period

• Need for anticoagulation at curative dose

• Contraindication to LMWH (previous heparin induced thrombopenia, hemostaticimpairment, known severe renal insufficiency)

• Women who received more than two doses of LMWH since delivery

• Unable or refusal to give informed consent

• Aspirin at a daily dose 100 mg or dual antiplatelet therapy

• Previous inclusion in Mum-VTE study

• Concomitant participation in another therapeutic study