Efficacy, Safety, Pharmacokinetics of ICP-488 in Patients With Moderate to Severe Plaque Psoriasis

Inclusion Criteria:

Eligible subjects must meet all of the following criteria:

1. Subjects voluntarily participate in this study and have signed informed consent.

2. Male or female subjects between the ages of 18 and 75 (including the threshold) atthe time of signing the ICF.

3. History of plaque psoriasis ≥6 months at baseline.

4. Subjects need to receive systemic therapy and/or phototherapy.

5. The following three criteria were met: a) psoriasis Area and Severity index (PASI)score ≥12; b) Psoriasis affected body surface area (BSA) ≥10%; c) Static physicianoverall assessment (sPGA) ≥3 scores

Exclusion Criteria:

1. The diagnosis was non-plaque psoriasis.

2. Subjects with concurrent skin diseases that the investigator believes wouldinterfere with the study assessments.

3. Presence of infection or immune-related disease.

4. Subjects with a history of TB or at risk for TB.

5. Received related treatment within the time window specified in the protocol.

6. An interval of less than 5 half-lives or 28 days (if any available half-life data)from the last dose of a strong CYP1A2/CYP3A4 inhibitor or inducer, or a plan to useconcurrently medications, dietary supplements or food (e.g., grapefruit orgrapefruit juice) with strong CYP1A2/CYP3A4 inhibitory or inductive effect duringstudy participation.

7. The investigator has determined that there are clinically significant test resultsand that participation in this trial would pose an unacceptable risk to patients; Orthe laboratory values of the subjects in the screening period meet the criteriaspecified in the protocol.

8. Pregnant or lactating women, or women who plan to become pregnant during studyparticipation.

9. A history of severe drug allergies.

10. Any other conditions in which the investigator considers it unsuitable for thesubject to participate in this study.