A Drug-drug Interaction Study With TS-172 in Healthy Adult Male Subjects

Inclusion Criteria:

• Japanese healthy adult males whose age is >=18 and <40 years at the time ofobtaining informed consent

• Subjects whose body mass index is >=18.5 and <25.0 at the screening test

• Subjects who are judged by a principal investigator or a sub-investigator to beeligible for participation in the study based on the results at the screening testand before administration of the drugs used in the study

• Subjects who have been informed of the clinical trial, understand the details of thetrial, and give their written consent prior to participation in the trial

Exclusion Criteria:

• Subjects with medical history ineligible for participation in the study such as ofrespiratory, cardiovascular, gastrointestinal, hepatic, renal, urologic, endocrine,metabolic, hematologic, immunologic, dermatologic, neurologic, or psychiatricdiseases

• Subjects with medical history of disease (e.g., stomach or intestinal ulcers) orsurgery (e.g., gastrectomy, gastric bandage, gastric bypass) that may affect theabsorption of the drugs used in the study

• Subjects who have been hospitalized with any treatment or undergone surgery within 12 weeks prior to receiving the drugs used in the study

• Subjects with medical history of drug allergies (limited to severe symptoms such asanaphylaxis) or significant allergic predispositions (e.g., asthma that requirestreatment)

• Subjects who have used medications (including over-the-counter drugs) within 2 weeksprior to receiving the drugs used in the study