CCSV - Post Market Clinical Follow-up Study

Last updated: February 14, 2025
Sponsor: Medical University of Vienna
Overall Status: Active - Recruiting

Phase

N/A

Condition

Heart Attack (Myocardial Infarction)

Circulation Disorders

Heart Failure

Treatment

N/A

Clinical Study ID

NCT06836908
CCSV 1
  • Ages > 18
  • All Genders

Study Summary

The main goal of this observational study is the evaluation of Chest Compression Synchronized Ventilation (CCSV) regarding oxygenation in terms of PaO2 assessed by routine blood gas analysis, hemodynamic effects, 30-day outcome and safety in comparison to Intermittent Positive Pressure Ventilation (IPPV) as data in humans is sparse especially in direct comparison to other ventilation modes.

Cardiac arrest patients in Vienna, Austria will be preclinically randomized (IPPV and CCSV) and ventilated accordingly during CPR. Differences in oxygenation, decarboxylation, systemic perfusion and cerebral oxygenation, the patient's 30-day outcome as well as ventilator-associated adverse events (e.g., pneumothorax) will be recorded and analyzed.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • OHCA

  • Correct endotracheal intubation (seen by capnography)

  • The patient is being treated by the Vienna Emergency Medical Services within thescope of emergency ventilation.

  • MEDUMAT Standard from Weinmann Emergency is used.

  • Mechanical ventilation is performed according to the specified indications.

Exclusion

Exclusion Criteria:

  • Patients eligible for eCPR (as defined by the standard operating procedure of theEmergency Medical Service Vienna)

  • Patients recovering (reaching sustained ROSC) before starting mechanical ventilationor in the first three minutes of it

  • Any other mechanical ventilation during the ongoing CPR before study inclusion

  • Traumatic cardiac arrest

  • Suspected or known pregnancy

  • Clinically suspected (tension-)pneumothorax

Study Design

Total Participants: 98
Study Start date:
June 01, 2024
Estimated Completion Date:
September 30, 2026

Connect with a study center

  • Medical University of Vienna

    Vienna, 1090
    Austria

    Active - Recruiting

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