Phase
Condition
Neurologic Disorders
Treatment
control
propranolol
Carvedilol
Clinical Study ID
Ages 18-75 All Genders
Study Summary
Eligibility Criteria
Inclusion
Inclusion Criteria:
- Patients with moderate & severe TBI detected on admission by CT scan and GCS scoreof ≤ 13 who either do not have any other injuries or only have associated minorinjuries.
Minor injuries are defined as presence of any of the following:
Mild intraperitoneal free fluid (IPFF) observed through abdominal ultrasound.
mild lung contusion detected in the chest CT scan.
hemothorax or pneumothorax present without accompanying symptoms of hypoxia,tachypnea, or respiratory distress.
simple limb fractures.
Exclusion
Exclusion Criteria:
Patients on pre-injury beta-blocker therapy.
Patients with any bronchospastic conditions.
Patients with active acute coronary syndrome.
TBI with GCS ≤ 13 with associated major injuries defined as the presence of any ofthe following:
Moderate & marked IPFF requiring surgical intervention ( laparotomy ).
moderate & marked lung contusion, pneumothorax & hemothorax with accompanyingsymptoms of hypoxia, tachypnea, lower limbs, or limb amputation.
Compound fracture in the upper or lower limb.
Open Faciomaxillary trauma.
Patients with persistent shock (systemic blood pressure <100 mmHg, base deficit > 4,or oliguria , HR < 60 b/min ) after > one week of admission.
Study Design
Connect with a study center
Zagazig University Hospitals
Zagazig,
EgyptSite Not Available
Zagazig University Hospitals, Zagazig,
Zagazig,
EgyptActive - Recruiting
Not the study for you?
Let us help you find the best match. Sign up as a volunteer and receive email notifications when clinical trials are posted in the medical category of interest to you.