Prospective Cohort Study Evaluating 18FDG PET-CT for the Early Prediction of the Efficacy of Immunotherapy Associated or Not With Chemotherapy in Patients With Locally Advanced or Metastatic Non-Small Cell Broncho-Pulmonary Carcinoma

Inclusion Criteria:

• Age greater than or equal to 18 years,

• Patients with histologically proven, metastatic or locally advanced NSCLC, withindication for immunotherapy (Nivolumab, pembrolizumab, atezolizumab, durvalumab,avelumab), in combination or not with chemotherapy molecules (carboplatin,cisplatin, pemetrexed, paclitaxel or nab-paclitaxel), validated by aMultidisciplinary Team and prescribed within the scope of their MarketedAuthorization, whatever the line of treatment treatment line,

• ECOG 0 to 3,

• The patient's understanding of the protocol and the note of non-opposition, withoral agreement,

• Patient has not objected to the use of his or her data for medical research.research,

• Patient has social security coverage.

Exclusion Criteria:

• Age under 18,

• Contraindication to 18FDG PET-CT examinations: severe claustrophobia, unbalanceddiabetes at the time of the first PET-CT scan (fasting capillary glucose ≥ 11 mmol),

• Hemoglobin less than 7 g/dL at inclusion. If the patient has a respiratory or orcardiovascular pathology, hemoglobin must not be less than 9.0 g/dL,

• Any participation in other biomedical studies involving the drug, medical devices ormedical devices or imaging techniques is prohibited, with the exception ofbiomedical studies,

• Refusal to participate in the present study,

• Contraindication (e.g. hypersensitivity to the active substance or to one of theexcipients of immunotherapy or chemotherapy treatments...).

• Vulnerable persons are defined in article L1121-5 to -8:

• Pregnant women, parturients and nursing mothers, persons deprived of theirliberty by judicial or administrative decision, persons hospitalized withoutconsent under articles L. 3212-1 and L. 3213-1 who are not covered by theprovisions of the provisions of article L. 1121-8,

• and persons admitted to a health or social establishment for purposes otherthan research purposes,

• adults who are the subject of a legal protection measure, or who are unable toexercise their non opposition