Real-World Study to Assess Subcutaneous Epcoritamab in Adult Participants With Diffuse Large B-Cell and Follicular Lymphoma

Last updated: September 2, 2025
Sponsor: AbbVie
Overall Status: Active - Recruiting

Phase

N/A

Condition

Lymphoproliferative Disorders

Follicular Lymphoma

Lymphoma

Treatment

N/A

Clinical Study ID

NCT06830759
P24-903
  • Ages > 18
  • All Genders

Study Summary

Diffuse large B-cell lymphoma (DLBCL) is an aggressive and rare cancer of a type of immune cells (a white blood cell responsible for fighting infections) and the most common type of non-Hodgkin lymphoma. Follicular Lymphoma (FL) is a slow-growing type of non-Hodgkin lymphoma. The purpose of this study is to assess the real-world effectiveness of subcutaneous epcoritamab in adult participants with advanced DLBCL and FL.

Epcoritamab is an investigational drug being developed for treating participants with DLBCL and FL. Approximately 700 participants will be enrolled in approximately 80 sites across 12-20 countries globally.

Participants will receive epcoritamab as prescribed by their physician in accordance with local country label. Participants will be followed for up to 3 years.

There is expected to be no additional burden for participants in this trial. Participants will attend regular visits during the study at a hospital or clinic according to their routine clinical practice.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Participants who are scheduled to be treated with epcoritamab for Treatment aftertwo or more prior lines of therapy 3L+ diffuse large B-cell lymphoma ((D)LBCL) or 3L+ Follicular lymphoma (FL).

  • Treatment with epcoritamab should be administered in accordance with the approvedlocal label in the participating country.

  • The decision to treat the participant should have been made by the clinician priorto, and independently of any decision to approach the participant to participate inthis study.

Exclusion

Exclusion Criteria:

  • Any condition included in the contraindications section of the approved localepcoritamab label in the participating country.

  • Participation in a concurrent interventional clinical trial (not includingnon-interventional/ observational study, PMOS, or registry participation) fromenrollment and throughout the study.

Study Design

Total Participants: 700
Study Start date:
March 28, 2025
Estimated Completion Date:
September 30, 2031

Connect with a study center

  • Hospital Britanico de Buenos Aires /ID# 274419

    Ciudad Autonoma de Buenos Aire, Buenos Aires 3435907 1280
    Argentina

    Active - Recruiting

  • Hospital Privado Universitario De Córdoba /ID# 274457

    Córdoba, Cordoba 5016
    Argentina

    Active - Recruiting

  • Hospital Privado Universitario De Córdoba /ID# 274457

    Córdoba 3860259, Córdoba Province 3860255 5016
    Argentina

    Active - Recruiting

  • Fundacion Argentina contra la Leucemia (FUNDALEU) /ID# 274390

    Buenos Aires, 1227
    Argentina

    Active - Recruiting

  • Hospital Británico de Buenos Aires /ID# 274419

    Buenos Aires, 1280
    Argentina

    Site Not Available

  • Fundacion Argentina contra la Leucemia (FUNDALEU) /ID# 274390

    Buenos Aires 3435910, 1227
    Argentina

    Active - Recruiting

  • Hospital Italiano de Buenos Aires /ID# 274418

    Buenos Aires 3435910, 1181
    Argentina

    Active - Recruiting

  • Krankenhaus Der Barmherzigen Brueder Graz /ID# 273288

    Graz, Steiermark 8020
    Austria

    Site Not Available

  • Krankenhaus Der Barmherzigen Brueder Graz /ID# 273288

    Graz 2778067, Styria 2764581 8020
    Austria

    Active - Recruiting

  • Algemeen Ziekenhuis klina /ID# 273405

    Brasschaat 2801117, Antwerpen 2930
    Belgium

    Active - Recruiting

  • Universitair Ziekenhuis Brussel /ID# 273403

    Jette 2794914, Brussels Capital 2800867 1090
    Belgium

    Active - Recruiting

  • Universitair Ziekenhuis Brussel /ID# 273403

    Jette, Bruxelles-Capitale 1090
    Belgium

    Site Not Available

  • Centre Hospitalier Epicura - site d'Hornu /ID# 273406

    Boussu, Hainaut 7301
    Belgium

    Site Not Available

  • Centre Hospitalier Epicura - Hornu /ID# 273406

    Boussu 2801226, Hainaut 7301
    Belgium

    Active - Recruiting

  • Grand Hôpital De Charleroi - Notre Dame /ID# 273728

    Charleroi, Hainaut 6000
    Belgium

    Site Not Available

  • Grand Hôpital De Charleroi - Notre Dame /ID# 273728

    Charleroi 2800481, Hainaut 6000
    Belgium

    Active - Recruiting

  • Helora /ID# 273726

    La Louvière, Hainaut 7100
    Belgium

    Site Not Available

  • Helora /ID# 273726

    La Louvière 2793508, Hainaut 7100
    Belgium

    Active - Recruiting

  • Ziekenhuis Oost-Limburg, Campus St.-Jan /ID# 273729

    Genk, Limburg 3600
    Belgium

    Site Not Available

  • Ziekenhuis Oost-Limburg, Campus St.-Jan /ID# 273729

    Genk 2797670, Limburg 3600
    Belgium

    Active - Recruiting

  • Vitaz /Id# 273408

    Sint-Niklaas, Oost-Vlaanderen 9100
    Belgium

    Site Not Available

  • Vitaz /Id# 273408

    Sint-Niklaas 2786578, Oost-Vlaanderen 9100
    Belgium

    Active - Recruiting

  • Az Damiaan Vzw /ID# 273714

    Ostend 2789786, West-Vlaanderen 8400
    Belgium

    Active - Recruiting

  • Umhat Sveti Ivan Rilsky /ID# 274898

    Sofiya, Sofia 727012 1606
    Bulgaria

    Active - Recruiting

  • University Multiprofile Hospital for Active Treatment Dr. Georgi Stranski /ID# 274893

    Pleven 728203, 5800
    Bulgaria

    Active - Recruiting

  • Specialized Hospital For Active Treatment Of Haematology Diseases /ID# 274955

    Sofia 727011, 1756
    Bulgaria

    Active - Recruiting

  • Cross Cancer Institute /ID# 271504

    Edmonton, Alberta T6G 1Z2
    Canada

    Site Not Available

  • Cross Cancer Institute /ID# 271504

    Edmonton 5946768, Alberta 5883102 T6G 1Z2
    Canada

    Active - Recruiting

  • Health Sciences North /ID# 274738

    Sudbury, Ontario P3E 5J1
    Canada

    Site Not Available

  • Health Sciences North /ID# 274738

    Greater Sudbury 5964700, Ontario 6093943 P3E 5J1
    Canada

    Active - Recruiting

  • Evangelismos Hospital /ID# 272736

    Athens 264371, Attica 6692632 10676
    Greece

    Active - Recruiting

  • General Hospital of Athens Laiko /ID# 272758

    Athens 264371, Attica 6692632 11527
    Greece

    Active - Recruiting

  • Metaxa Cancer Hospital Of Piraeus /ID# 273623

    Piraeus 255274, Attica 6692632 18537
    Greece

    Active - Recruiting

  • Evangelismos Hospital /ID# 272736

    Athens, Attiki 10676
    Greece

    Site Not Available

  • General Hospital of Athens Laiko /ID# 272758

    Athens, Attiki 11527
    Greece

    Active - Recruiting

  • Metaxa Cancer Hospital Of Piraeus /ID# 273623

    Piraeus, Attiki 18537
    Greece

    Site Not Available

  • University General Hospital of Alexandroupoli /ID# 272737

    Alexandroupoli, Evros 68100
    Greece

    Site Not Available

  • University General Hospital of Alexandroupoli /ID# 272737

    Alexandroupoli 736928, Evros 68100
    Greece

    Active - Recruiting

  • University Hospital of Ioannina /ID# 272739

    Ioannina, 45500
    Greece

    Site Not Available

  • University Hospital of Ioannina /ID# 272739

    Ioannina 261779, 45500
    Greece

    Active - Recruiting

  • General Hospital Of Thessaloniki G. Papanikolaou /ID# 275323

    Thessaloniki, 57010
    Greece

    Site Not Available

  • Papageorgiou General Hospital /ID# 272735

    Thessaloniki, 56429
    Greece

    Active - Recruiting

  • General Hospital Of Thessaloniki G. Papanikolaou /ID# 275323

    Thessaloniki 734077, 57010
    Greece

    Active - Recruiting

  • Papageorgiou General Hospital /ID# 272735

    Thessaloniki 734077, 56429
    Greece

    Active - Recruiting

  • Tel Aviv Sourasky Medical Center /ID# 271615

    Tel Aviv 293397, Tel Aviv 293396 6423906
    Israel

    Active - Recruiting

  • Tel Aviv Sourasky Medical Center /ID# 271615

    Tel Aviv, Tel-Aviv 6423906
    Israel

    Site Not Available

  • Hadassah Medical Center-Hebrew University /ID# 271616

    Jerusalem 281184, 91120
    Israel

    Active - Recruiting

  • Rabin Medical Center /ID# 271614

    Petah Tikva, 4941492
    Israel

    Site Not Available

  • Rabin Medical Center /ID# 271614

    Petah Tikva 293918, 4941492
    Israel

    Active - Recruiting

  • I.R.C.C.S Istituto Tumori Giovanni Paolo II /ID# 274217

    Bari 3182351, 70124
    Italy

    Active - Recruiting

  • Ospedale La Maddalena /ID# 274411

    Palermo 2523920, 90146
    Italy

    Active - Recruiting

  • Complejo Hospitalario Universitario A Coruña /ID# 272040

    A Coruña, A Coruna 15006
    Spain

    Site Not Available

  • Complejo Hospitalario Universitario A Coruña /ID# 272040

    A Coruña 3119841, A Coruna 15006
    Spain

    Active - Recruiting

  • Hospital Universitario Reina Sofia /ID# 272051

    Córdoba, Cordoba 14004
    Spain

    Site Not Available

  • Hospital Universitario Reina Sofia /ID# 272051

    Córdoba 2519240, Cordoba 14004
    Spain

    Active - Recruiting

  • Hospital Costa del Sol /ID# 272431

    Marbella 2514169, Malaga 29603
    Spain

    Active - Recruiting

  • Hospital Universitario de Valme /ID# 272050

    Seville, Sevilla 41014
    Spain

    Site Not Available

  • Hospital Universitario de Valme /ID# 272050

    Seville 2510911, Sevilla 41014
    Spain

    Active - Recruiting

  • Hospital de Manises /ID# 272046

    Manises, Valencia 46940
    Spain

    Site Not Available

  • Hospital de Manises /ID# 272046

    Manises 2514197, Valencia 2593113 46940
    Spain

    Active - Recruiting

  • Hospital Universitario De Burgos /ID# 272066

    Burgos 3127461, 09006
    Spain

    Active - Recruiting

  • Hospital Universitario Nuestra Señora de Candelaria /ID# 272413

    Santa Cruz de Tenerife, 38010
    Spain

    Site Not Available

  • Hospital Universitario Nuestra Señora de Candelaria /ID# 272413

    Santa Cruz de Tenerife 2511174, 38010
    Spain

    Active - Recruiting

  • Hospital Clinico Universitario de Valladolid /ID# 272042

    Valladolid 3106672, 47003
    Spain

    Active - Recruiting

  • Milton Keynes Hospital /ID# 272817

    Milton Keynes 2642465, Buckinghamshire MK6 5LD
    United Kingdom

    Active - Recruiting

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