Investigating the Relationship Between Temporal Bone CT, Bone Density, and Hearing Loss in Otosclerosis Patients

Last updated: February 19, 2025
Sponsor: İbrahim Emir Yeşil
Overall Status: Active - Recruiting

Phase

N/A

Condition

Hearing Loss

Bone Density

Hearing Impairment

Treatment

N/A

Clinical Study ID

NCT06830187
HacettepeU-SBA 24/365
  • Ages > 18
  • All Genders

Study Summary

The goal of this observational case-control study is to evaluate the relationship between temporal bone computed tomography (CT) findings, bone mineral density (BMD), and audiological parameters in adults diagnosed with otosclerosis. The main questions it aims to answer are:

Is there a correlation between temporal bone CT density values and the severity of hearing loss in otosclerosis? Do bone mineral density and serum vitamin D levels differ between otosclerosis patients and individuals without otosclerosis? Researchers will compare patients diagnosed with otosclerosis to a control group without otosclerosis to determine if CT-based density variations are associated with disease severity and systemic bone metabolism markers.

Participants who have already had a temporal bone CT scan as part of their routine clinical evaluation will undergo:

Bone mineral density (BMD) assessment via dual-energy X-ray absorptiometry (DEXA) Serum vitamin D level measurement Audiological testing, including pure tone audiometry and speech discrimination tests This study aims to improve the diagnostic and prognostic understanding of otosclerosis by integrating imaging, metabolic, and audiological data.

Eligibility Criteria

Inclusion

Inclusion Criteria (Otosclerosis Group):

  • Adults diagnosed with otosclerosis based on audiological and clinical assessment

  • Patients with available high-resolution CT scans and audiological data

  • Individuals who have undergone stapedectomy or stapedotomy surgery

  • Availability of bone mineral density and serum vitamin D data

Inclusion Criteria (Control Group):

  • Patients without otosclerosis but with temporal CT imaging for other indications

  • No history of conductive or mixed hearing loss

  • Availability of BMD and vitamin D data

Exclusion

Exclusion Criteria:

  • History of primary metabolic bone diseases (osteoporosis, Paget's disease)

  • Use of medications affecting bone metabolism (bisphosphonates, corticosteroids)

  • History of chronic otitis media or prior ear surgeries

  • Patients who received head and neck radiotherapy

Study Design

Total Participants: 86
Study Start date:
January 01, 2022
Estimated Completion Date:
May 01, 2025

Connect with a study center

  • Hacettepe University Hospitals

    Ankara, 06560
    Turkey

    Active - Recruiting

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