Hyperthermia refers to treating diseases with temperatures beyond normal body temperature
(39-45℃), and moxibustion therapy of traditional Chinese medicine belongs to the category
of hyperthermia. It has been reported at home and abroad that the local temperature of
44℃ can effectively mobilize the body's immunity and remove HPV infection lesions, such
as condyloma acuminatum and verruca vulgaris. Our research group conducted randomized
controlled experiments on patients with viral warts in the early clinical practice, and
the cure rate of the hyperthermia group reached 45-55%, which was superior to the
traditional method in the aspects of no trauma, low recurrence rate, easy to tolerate and
so on. Our research group's preliminary research on hyperthermia of viral warts has been
included in the British Medical Association's guidelines for viral warts therapy. The
equipment our research group developed has been obtained the medical device registration
certificate, and is in the process of national promotion. Hyperthermia is to mobilize
systemic immunity through local warm heat, the preliminary clinical study of the research
group shows that the therapeutic effect of hyperthermia is usually "all or none": "all"
that is, after hyperthermia, all viral warts are removed, including non-treatment
lesions;"None" means that some patients with viral warts do not respond to hyperthermia.
Cellular immunity plays a very important role in the removal of warts. At present, some
special clinical patients such as pregnant women, children, patients with autoimmune
diseases, diabetes, immunosuppressants after organ transplantation and other patients
with skin/mucosal HPV infection, their warts show more extensive proliferation or a
longer and repeated course of disease, treatment resistance, etc. It has increased the
difficulty of clinical treatment, and the specific mechanism is still unclear. Therefore,
for these special populations, how to further enhance the therapeutic effect of
hyperthermia is the top priority of current research.
In view of the above findings, this research group intends to study the efficacy and
safety of hyperthermia in the treatment of viral warts in the special population
(pregnant women, children, patients with autoimmune diseases, diabetes, and
immunosuppressants after organ transplantation, etc.) in a multicenter real-world study
of skin/mucosal HPV infection in the special population.