Effect of Er,Cr:YSGG Sub-Ablative Laser Irradiation on Fissure Caries Prevention in Permanent Molars

Last updated: February 12, 2025
Sponsor: Alexandria University
Overall Status: Active - Recruiting

Phase

N/A

Condition

N/A

Treatment

Fluoride varnish application

sub-ablative Er,Cr:YSGG laser

Clinical Study ID

NCT06826456
10556-0008839
  • Ages 6-12
  • All Genders
  • Accepts Healthy Volunteers

Study Summary

Background: Subjecting human dental enamel to sub-ablative laser has been suggested as a novel way of caries prevention. However, further studies are needed to establish its use as a routine clinical procedure for caries prevention.

The aim of this study: This study aims to evaluate the effect of Er,Cr:YSGG subablative laser irradiation on caries resistance of occlusal fissures of permanent molars.

Materials and methods: In-vivo study, a split mouth randomized controlled trial with sixty patients having two fully erupted bilateral first permanent molars (ICDAS-II score 0,1 or 2). The pits and fissures will be subjected to sub-ablative power of Er,Cr:YSGG Laser (Group 1, n=90) and will be compared with fluoride varnish application on the first permanent molars in the same arch(Group 2,n=90). DIAGNOdentTM readings and changes in ICDAS-II score will be assessed at base line and at 3,6,9 and 12 months follow-up.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Participants of age 6-12 years old

  • Patients ranking definitely positive or positive on Frankl behavior rating scale

  • Having at least two bilateral fully erupted first permanent molars with untreatednon-cavitated occlusal surfaces with deep grooves, the included teeth will haveInternational Detection and Assessment System (ICDAS-II)/ severity scores 0, 1 or 2

  • Initial DIAGNOdent Score not exceeding value of 25 indicating only enamelinvolvement

  • Patients whom their parents are willing to comply with all study procedures andprotocols and will be given an informed consent to participate

Exclusion

Exclusion Criteria:

  • Patients with any known medical history of systemic diseases

  • Patients having first permanent molar with hypoplastic or hypocalcified enamel

  • Patients using medications that may affect the oral flora or salivary flow

  • Patients treated with in-office fluoride treatment within the last 3 months prior tobeing enrolled in the study.

  • Patients showing evidence of poor oral hygiene according to Silness and Löe plaqueindex

Study Design

Total Participants: 60
Treatment Group(s): 2
Primary Treatment: Fluoride varnish application
Phase:
Study Start date:
January 01, 2024
Estimated Completion Date:
August 31, 2025

Connect with a study center

  • Alexandria University

    Alexandria,
    Egypt

    Active - Recruiting

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