Gastric Feeding Versus Transpyloric Feeding in Infants with Severe Bronchopulmonary Dysplasia, a Crossover Study

Last updated: February 6, 2025
Sponsor: Le Bonheur Children's Hospital
Overall Status: Active - Recruiting

Phase

N/A

Condition

Lung Disease

Treatment

Gastric feeding

Transpyloric feeding

Clinical Study ID

NCT06821776
24-10394-FB
  • Ages 1-1
  • All Genders

Study Summary

Hospitalized infants with severe bronchopulmonary dysplasia (BPD) and feeding intolerance will be randomized to 2 weeks of continuous gastric feeding or continuous transpyoloric feeding. Subjects will crossover after 2 weeks and receive 4 weeks of each feeding mode. Respiratory status will be assessed to determine the optimal feeding mode for each infant.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Patients born <32 weeks' gestation

  • Currently admitted to the Le Bonheur NICU

  • Grad 2 or 3 BPD (positive pressure or intubated at 36 weeks PMA)

  • Signs of gastroesophageal reflux, chronic aspiration, or other feeding intolerance.

Exclusion

Exclusion Criteria:

  • Known gastrointestinal anomalies

  • Unable to tolerate ≥100mL/kg/day enteral feeding

  • Congenital anomalies likely to alter feeding techniques

  • Surgical feeding tube in place or expected within the next 8 weeks

  • Expected to remain hospitalized <8 weeks

Study Design

Total Participants: 25
Treatment Group(s): 2
Primary Treatment: Gastric feeding
Phase:
Study Start date:
February 05, 2025
Estimated Completion Date:
February 28, 2030

Connect with a study center

  • Le Bonheur Children's Hospital

    Memphis, Tennessee 38103
    United States

    Active - Recruiting

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