Comparison of Clomid and Lezra With Lezra for Ovulation Induction in Clomid Resistant PCOS Case

Last updated: May 4, 2026
Sponsor: HITEC-Institute of Medical Sciences
Overall Status: Completed

Phase

1

Condition

Polycystic Ovarian Syndrome

Reproductive Health

Treatment

Clomiphene Citrate and letrozole

Clinical Study ID

NCT06813118
HITECIMSTAXILLA
  • Ages 20-40
  • Female
  • Accepts Healthy Volunteers

Study Summary

Clomiphene citrate resistant i.e failure to ovulate after 6 cycles of ovulation induction effects 15-40% of patients with PCOS.Two treatment groups will be formed one recieving letrozole alone and another recieving CC and letrozole combined.Mature follicles and endometrial thickness will be checked by transvaginal ultrasound and results will be recorded.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • women of 20-40 years with a history of PCOS and resistant to CC

Exclusion

Exclusion Criteria:

  • Premature ovarian insufficiency

  • Husband has oligo azoospermia

  • Hypothyroidism

  • Hyperprolactinemia

Study Design

Total Participants: 42
Treatment Group(s): 1
Primary Treatment: Clomiphene Citrate and letrozole
Phase: 1
Study Start date:
June 07, 2024
Estimated Completion Date:
March 25, 2025

Study Description

Subfertility is characterized by the inability to achieve conception despite engaging in regular unprotected sexual intercourse for 1-2 years.PCOS exhibits chacteristic traits such as obesity,heightened insulin resistance accompanied by compensatory hyperinsulinemia,oligo/anovulation and subfertility.Clompiphene citrate induces ovarian stimulation.Letrozole ,an aromatase inhibitor emerges as a novel medication with comparable efficacy to CC as a first line treatment for inducing ovulation in cases of anovulation.

Connect with a study center

  • HIT Hospital

    Rawalpindi, Punjab Province 47080
    Pakistan

    Site Not Available

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