Human Leukocyte Antigen (HLA) Mismatched Unrelated Allogeneic Hematopoietic Stem Cell Transplantation

Inclusion Criteria:

• Adult patients (18-60 years old) with hematological malignancies and indications forhematopoietic stem cell transplantation;

• Non blood donors without human leukocyte antigen (HLA) high-resolution typing ≥ 9/10, or those who have difficulty finding non blood donors due to urgent medicalconditions;

• No suitable HLA matching haploidentical donor available;

• There are suitable unrelated HLA mismatched (HLA high-resolution typing<9/10)donors;

• The subjects or their legal representatives shall sign an informed consent formbefore the start of the clinical study.

Exclusion Criteria:

• Patients with severe liver and kidney function (alanine aminotransferase>2.5 timesthe upper limit of normal, blood creatinine>1.5 times the upper limit of normal) andcardiopulmonary dysfunction (New York Heart Association (NYHA) III/IV heartfunction, ejection fraction<50%, severe obstructive or restrictive ventilationdysfunction);

• Merge active infections;

• Eastern Cooperative Oncology Group Performance Status (ECOG) score ≥ 2 points;

• Secondary tumors with merged activity;

• Severe central nervous system or mental illness leading to the inability toautonomously choose to enter or exit clinical trials;

• Combine other allo hematopoietic stem cell transplantation (HSCT) contraindications.