Human Leukocyte Antigen (HLA) Mismatched Related Allogeneic Hematopoietic Stem Cell Transplantation

Inclusion Criteria:

• Adult patients (18-60 years old) with hematological malignancies and indications forhematopoietic stem cell transplantation with no available related human leukocyteantigen (HLA) identical sibling donors;

• No available donor with HLA high-resolution typing ≥ 9/10 or those who havedifficulty finding donors due to urgent medical conditions;

• No suitable HLA matching haploidentical donor available;

• There is a suitable donor with mismatched HLA typing;

• The subjects or their legal representatives shall sign an informed consent formbefore the start of the clinical study.

Exclusion Criteria:

• Patients with severe liver and kidney function (alanine aminotransferase>2.5 timesthe upper limit of normal, blood creatinine>1.5 times the upper limit of normal) andcardiopulmonary dysfunction (New York Heart Association (NYHA) III/IV heartfunction, ejection fraction<50%, severe obstructive or restrictive ventilationdysfunction);

• Merge active infections;

• Eastern Cooperative Oncology Group (ECOG) score ≥ 2 points;

• Secondary tumors with merged activity;

• Severe central nervous system or mental illness leading to the inability toautonomously choose to enter or exit clinical trials;

• Combine other allo HSCT contraindications.