Effects of Tranexamic Acid Irrigation on Impacted Third Molar Surgery

Last updated: June 23, 2025
Sponsor: Bezmialem Vakif University
Overall Status: Active - Recruiting

Phase

N/A

Condition

Extraction

Hemorrhage

Treatment

Tranexamic acid

saline irrigation

Clinical Study ID

NCT06806241
E.142551
  • Ages 14-40
  • All Genders
  • Accepts Healthy Volunteers

Study Summary

Tranexamic acid (TXA) is an effective hemostatic agent used to reduce blood loss and the need for transfusion. It is a relatively safe drug with minimal significant side effects. The most commonly reported complications include nausea, diarrhea, and occasional orthostatic reactions. The increased risk of thromboembolic events associated with the drug is the most serious complication; however, this has not been reported in most clinical studies and remains uncertain. Based on experience from other types of surgeries, tranexamic acid appears to be safe for use without an increased risk of venous thrombosis. To mitigate systemic absorption and minimize undesirable side effects, TXA can be applied topically rather than intravenously, reducing the risk of venous thromboembolism.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  1. Indicated for the Extraction of Bilaterally Impacted Third Molars with BoneRetention.

  2. Systemically healthy patients aged 14-40 years with no bleeding disorders.

Exclusion

Exclusion Criteria:

  1. Patients with systemic diseases affecting general health.

  2. Patients diagnosed with any bleeding disorder.

  3. Patients with advanced infection or cysts associated with the impacted tooth.

Study Design

Total Participants: 20
Treatment Group(s): 2
Primary Treatment: Tranexamic acid
Phase:
Study Start date:
January 01, 2025
Estimated Completion Date:
March 10, 2026

Study Description

Topical TXA irrigation has recently begun to be used intraoperatively. In a study conducted by Eftekharian et al., the application of intraoperative 1% TXA irrigation solution during bimaxillary orthognathic surgery was found to be significantly associated with a reduction in intraoperative blood loss compared to placebo. Additionally, the topical application of TXA to the maxillary sinus during endoscopic sinus surgery has been shown to reduce intraoperative blood loss. In the current literature, the use of tranexamic acid irrigation during tooth extraction under local anesthesia has not been reported. Our study aims to demonstrate the effectiveness of TXA irrigation during the extraction of bone-retained teeth and its effect on postoperative edema.

Connect with a study center

  • Bezmialem Vakıf Universty

    Istanbul, Fatih 34093
    Turkey

    Active - Recruiting

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