Impact of Depression on Thermoregulation

Inclusion Criteria:

• Non-depressed adults aged 18-40 years;

• OR adults aged 18-40 years with clinically diagnosed major depressive disorderaccording to DSM-V criteria not currently receiving antidepressant treatment;

• OR adults aged 18-40 years with clinically diagnosed major depressive disorder withat least 2 weeks of treatment with a selective serotonin reuptake inhibitor;

• OR aged 18-40 years adults with clinically diagnosed major depressive disorder withat least 2 weeks of treatment with a serotonin norepinephrine reuptake inhibitor;

• All participants will be asymptomatic and no signs/symptoms of disease according tothe American College of Sports Medicine 10th edition Guidelines for Exercise Testingand Prescription (chest pain or pressure, dizziness, joint pain, and signs ofcardiovascular disease);

• Systolic blood pressure 140 mmHg and diastolic pressure 90 mmHg at screening;

• Non-diabetic

• Not taking any other medications that might affect the physiological variables ofinterest (beta blockers, tricyclic antidepressants, antipyretics, diuretics, etc.);;

• Between the 20th and 80th percentiles for sex- and age-appropriate VO2max accordingto the American College of Sports Medicine 10th edition Guidelines for ExerciseTesting and Prescription;

• English proficiency;

• Capable of providing informed consent.

Exclusion Criteria:

• BMI > 35

• Are pregnant or planning to become pregnant in the next 12 months;

• Concurrently participate in another study involving physical activity or weightloss;

• Plan to have surgery or relocate outside the area within the next year;

• Medications that could alter cardiovascular or thermoregulatory responses toexercise (beta blockers, antipyretics, tricyclic antidepressants, diuretics, etc.);

• Allergy to latex or adhesive;

• Tobacco use;

• Illegal/recreational drug use;

• Exertional chest pain or musculoskeletal pain;

• Contraindications to a maximal exercise test or an indication for early terminationof the exercise test according to the American College of Sports Medicine 10thedition Guidelines for Exercise Testing and Prescription;

• Abnormal resting or exercise electrocardiogram (ECG);

• Any bleeding disorders, gastric ulcers, allergies to NSAIDS, asthma, kidney/liverdisorders, and taking any other anticoagulants;

• History of Crohn's disease, diverticulitis, or similar gastrointestinal disease;

• Co-morbid psychiatric disorders (psychosis, schizophrenia, bipolar disorder, panicdisorder, obsessive compulsive disorder, etc.);

• Active suicidal ideation (moderate or high suicidality);

• Use of psychoactive or psychopharmacological drugs other than SSRI and SNRIs withinone year of participating.