Urethral PeRfusion Index-Guided Hemodynamic ManagemenT in Patients Having Major Abdominal Surgery: the UPRIGHT Randomized Feasibility Trial

Last updated: February 19, 2025
Sponsor: Universitätsklinikum Hamburg-Eppendorf
Overall Status: Active - Recruiting

Phase

N/A

Condition

N/A

Treatment

urethal perfusion index monitoring

Clinical Study ID

NCT06799832
2024-101408-BO-ff
  • Ages > 45
  • All Genders

Study Summary

We will perform this single-center pilot trial to determine if the intraoperative urethral perfusion index is higher in patients assigned to maintaining postinduction baseline urethral perfusion index than in patients assigned to routine care (with blinded urethral perfusion index monitoring). As pre-planned substudies, we will also assess the agreement between a) urethral perfusion index-derived pulse rate and heart rate measured with an electrocardiogram and b) between the urethral perfusion index and the peripheral perfusion index.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • at least 45 years old

  • scheduled for elective major abdominal surgery (involving visceral organs with anexpected duration of at least 120 minutes)

  • indication for an arterial catheter

  • indication for an urinary catheter

Exclusion

Exclusion Criteria:

  • Pregnancy

  • Planned surgery: nephrectomy, liver or kidney transplantation surgery

  • Patients who previously had surgery on the urethra or bladder

  • Patients without clinical indication for continuous blood pressure monitoring withan intraarterial catheter

Study Design

Total Participants: 116
Treatment Group(s): 1
Primary Treatment: urethal perfusion index monitoring
Phase:
Study Start date:
January 21, 2025
Estimated Completion Date:
July 31, 2025

Connect with a study center

  • University Medical Center Hamburg-Eppendorf

    Hamburg,
    Germany

    Active - Recruiting

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