Standard Care With or Without Early Palliative Care Provided by Palliative Care Specialist in Advanced Non-small Cell Lung Cancer Patients

Last updated: January 20, 2025
Sponsor: Mahidol University
Overall Status: Active - Recruiting

Phase

N/A

Condition

N/A

Treatment

Early palliative care integration

Standard systemic treatment for advanced lung cancer

Clinical Study ID

NCT06786468
068/2567(IRB3)
  • Ages > 18
  • All Genders

Study Summary

Early palliative care has been shown to improve the survival of advanced lung cancer patients. However, most of the clinical studies were performed in the era when systemic treatment options for this disease were limited. Currently, many effective treatment options are available, including targeted therapy and immunotherapy. These novel agents improve the treatment outcomes while having less toxicity compared to conventional chemotherapy. Moreover, medical oncologists are now trained to provide palliative care for patients. This study was designed to demonstrate whether early palliative care provided by the palliative care specialist still improves the quality of life or survival of advanced lung cancer patients compared to standard care provided by the medical oncologist.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Age at least 18 years old

  • Pathologically confirmed advanced non-small cell lung cancer

  • Plan to receive systemic treatment for lung cancer within three weeks

  • ECOG performance status 0-2 with estimated life expectancy > 24 weeks

  • Having at least 4 scores according to Edmonton Symptom Assessment System (ESAS)

  • Able to complete the questionnaires

Exclusion

Exclusion Criteria:

  • Had received systemic treatment for advanced lung cancer before

Study Design

Total Participants: 104
Treatment Group(s): 2
Primary Treatment: Early palliative care integration
Phase:
Study Start date:
April 02, 2024
Estimated Completion Date:
April 30, 2027

Study Description

Advanced non-small cell lung cancer patients initiating a systemic treatment will be randomized to the early palliative care arm (attending a palliative care clinic once a month during the first three months concurrently with oncology clinic appointment) or the standard care arm (attending oncology clinic only). The patients will be asked to complete the quality of life questionnaires (FACT-L, EQ-5D-5L), mental health questionnaire (PHQ-9), and pain assessment once a month for three months and at the sixth month.

Connect with a study center

  • Siriraj Hospital

    Bangkok, 10700
    Thailand

    Active - Recruiting

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