Fexofenadine As Adjuvant Therapy in Parkinson Disease

Last updated: January 17, 2025
Sponsor: Tanta University
Overall Status: Active - Recruiting

Phase

2/3

Condition

N/A

Treatment

Fexofenadine

Levodopa/carbidopa

Clinical Study ID

NCT06785298
3245
  • Ages 50-70
  • All Genders

Study Summary

Parkinson's disease (PD) is a chronic, progressive neurological disorder characterized by both motor and non-motor symptoms. PD is the second most common neurodegenerative disorder after Alzheimer's disease and the most common movement disorder. PD has age-related pathology; it is present in 1-2% of the population over 60 years of age. The disease is characterized by a triad of disordered voluntary motor activity in the form of bradykinesia (slowness of movement) or even akinesia (absence of movement),rigidity and postural instability, and a resting tremor of the hands and less commonly the feet.

Eligibility Criteria

Inclusion

Inclusion Criteria:• Age ≥ 50 years. Both male and female will be included. Patients with Parkinson's disease on dopamine replacement therapy. Modified Hoehn and Yahr stage, MHY 1-4

Exclusion

Exclusion Criteria:• Atypical parkinsonism or drug-induced parkinsonism Breast feeding Pregnant women and women with planned pregnancy. Patients with significant liver and kidney function abnormalities. History/presence of acute heart disease Alcohol and / or drug abusers. Patients with known allergy to the study medications Other medical conditions that can interfere with results or endanger the participant.

Study Design

Total Participants: 46
Treatment Group(s): 2
Primary Treatment: Fexofenadine
Phase: 2/3
Study Start date:
December 10, 2024
Estimated Completion Date:
December 20, 2026

Connect with a study center

  • Tanta University

    Tanta, 31511
    Egypt

    Active - Recruiting

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