A Study to Investigate Effects of Ocrelizumab Treatment on Neurofilament Light Chain (NfL) Levels and Participant Satisfaction in Participants With Multiple Sclerosis (MS)

Last updated: April 24, 2026
Sponsor: Hoffmann-La Roche
Overall Status: Active - Recruiting

Phase

N/A

Condition

Scar Tissue

Neurologic Disorders

Multiple Sclerosis

Treatment

Ocrelizumab

Clinical Study ID

NCT06780150
ML45551
  • Ages > 18
  • All Genders

Study Summary

The main purpose of the study is to evaluate participant satisfaction after administration of ocrelizumab subcutaneous (SC) after 12 months using the therapy administration satisfaction questionnaire subcutaneous (TASQ-SC).

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Diagnosis of MS

  • RMS and PPMS participants diagnosed according to the McDonald criteria of 2017

  • First treatment during the course of MS therapy with ocrelizumab SC according to thelocal prescribing information, regardless of the reason for starting treatment withocrelizumab

Exclusion

Exclusion Criteria:

  • Participation in interventional studies investigating DMTs for MS

  • Prior or simultaneous participation in CONFIDENCE or MoOzaRt (ISRCTN55332718) noninterventional study (NIS) at the same study site

  • Prior treatment with rituximab (MabThera®) or ublituximab (Briumvi®)

  • Severe psychiatric disability

  • Pregnant women

Study Design

Total Participants: 842
Treatment Group(s): 1
Primary Treatment: Ocrelizumab
Phase:
Study Start date:
September 26, 2024
Estimated Completion Date:
March 31, 2028

Connect with a study center

  • Uniklinik RWTH Aachen

    Aachen, 52074
    Germany

    Active - Recruiting

  • Uniklinik RWTH Aachen

    Aachen 3247449, 52074
    Germany

    Site Not Available

  • Gesundheitszentrum St. Marien GmbH

    Amberg, 92224
    Germany

    Active - Recruiting

  • Neuropraxis im Stadtpalais Dres. Ulzheimer/Herröder/Wessig GbR

    Aschaffenburg, 63739
    Germany

    Active - Recruiting

  • Neuropraxis im Stadtpalais Dres. Ulzheimer/Herröder/Wessig GbR

    Aschaffenburg 2955272, 63739
    Germany

    Site Not Available

  • Neurologie Bad Soden

    Bad Soden, 65812
    Germany

    Active - Recruiting

  • Neurologie Bad Soden

    Bad Soden 11611307, 65812
    Germany

    Site Not Available

  • Neurologische Praxis - Kallmann Neurologie - mszb

    Bamberg, 96052
    Germany

    Active - Recruiting

  • Neurologische Praxis - Kallmann Neurologie - mszb

    Bamberg 2952984, 96052
    Germany

    Site Not Available

  • Jüdisches Krankenhaus Berlin

    Berlin, 13347
    Germany

    Active - Recruiting

  • NEUROZENTRUM tempelhof.berlin

    Berlin, 12099
    Germany

    Active - Recruiting

  • NeuroZentrum Zehlendorf Dr. Ringel und Dr. Scherer

    Berlin, 14169
    Germany

    Active - Recruiting

  • Neurologisches Facharztzentrum Berlin am Sankt Gertrauden-Krankenhaus

    Berlin, 10713
    Germany

    Active - Recruiting

  • Neurologisches Zentrum für Bewegungsstörungen und Diagnostik

    Berlin, 14195
    Germany

    Active - Recruiting

  • Praxis Dr. Said Masri

    Berlin, 12099
    Germany

    Active - Recruiting

  • Jüdisches Krankenhaus Berlin

    Berlin 2950159, 13347
    Germany

    Active - Recruiting

  • NEUROZENTRUM tempelhof.berlin

    Berlin 2950159, 12099
    Germany

    Active - Recruiting

  • NeuroZentrum Zehlendorf Dr. Ringel und Dr. Scherer

    Berlin 2950159, 14169
    Germany

    Site Not Available

  • Neurologisches Facharztzentrum Berlin am Sankt Gertrauden-Krankenhaus

    Berlin 2950159, 10713
    Germany

    Active - Recruiting

  • Neurologisches Zentrum für Bewegungsstörungen und Diagnostik

    Berlin 2950159, 14195
    Germany

    Active - Recruiting

  • Praxis Dr. Said Masri

    Berlin 2950159, 12099
    Germany

    Active - Recruiting

  • Gemeinschaftspraxis Dr. Wolfram von Pannwitz, MBA & Dr. med. Marie Perle Brinckmann

    Berlin-Steglitz, 12163
    Germany

    Site Not Available

  • St. Josef-Hospital

    Bochum, 44791
    Germany

    Active - Recruiting

  • St. Josef-Hospital

    Bochum 2947416, 44791
    Germany

    Site Not Available

  • Dres. Lippert/Kausch

    Bogen, 94327
    Germany

    Active - Recruiting

  • Dres. Lippert/Kausch

    Bogen 2947026, 94327
    Germany

    Site Not Available

  • Krankenhaus Buchholz Abt. Neurologie

    Buchholz, 21244
    Germany

    Active - Recruiting

  • Krankenhaus Buchholz Abt. Neurologie

    Buchholz 2942358, 21244
    Germany

    Site Not Available

  • Allgemeines Krankenhaus Celle / Klinik für Neurologie

    Celle, 29223
    Germany

    Active - Recruiting

  • Neuropraxis Celle: Praxis für Neurologie & Psychatrie

    Celle, 29223
    Germany

    Active - Recruiting

  • Neuropraxis Celle: Praxis für Neurologie & Psychatrie

    Celle 2940213, 29223
    Germany

    Site Not Available

  • Praxisgemeinschaft Dres. Sylke Domke und Vasil Gjaurov

    Chemnitz, 09117
    Germany

    Active - Recruiting

  • Praxisgemeinschaft Dres. Sylke Domke und Vasil Gjaurov

    Chemnitz 2940132, 09117
    Germany

    Site Not Available

  • NeuroMed Campus Neurologische Gemeinschaftspraxis am St. Elisabeth Krankenhaus

    Cologne, 50935
    Germany

    Active - Recruiting

  • NeuroMed Campus Neurologische Gemeinschaftspraxis am St. Elisabeth Krankenhaus

    Cologne 2886242, 50935
    Germany

    Site Not Available

  • Gemeinschaftspraxis Dr. med. Josef Leclaire und Dr. med. Thomas Rotermund

    Dortmund, 44137
    Germany

    Site Not Available

  • Gemeinschaftspraxis Dr. med. Josef Leclaire und Dr. med. Thomas Rotermund

    Dortmund 2935517, 44137
    Germany

    Site Not Available

  • Gemeinschaftspraxis für Neurologie

    Düsseldorf, 40211
    Germany

    Active - Recruiting

  • Nervenarztpraxis Gerresheim

    Düsseldorf, 40625
    Germany

    Active - Recruiting

  • Universitätsklinikum Düsseldorf

    Düsseldorf, 40225
    Germany

    Active - Recruiting

  • Gemeinschaftspraxis für Neurologie

    Düsseldorf 2934246, 40211
    Germany

    Active - Recruiting

  • Universitätsklinikum Düsseldorf

    Düsseldorf 2934246, 40225
    Germany

    Site Not Available

  • Gemeinschaftspraxis für Neurologie und Psychiatrie, Psychotherapie

    Eltville, 65343
    Germany

    Active - Recruiting

  • Gemeinschaftspraxis für Neurologie und Psychiatrie, Psychotherapie

    Eltville 2930646, 65343
    Germany

    Site Not Available

  • NeuroCentrum Odenwald

    Erbach/Odenwald, 64711
    Germany

    Active - Recruiting

  • Universitätsklinikum Erlangen, Neurologische Klinik

    Erlangen, 91054
    Germany

    Active - Recruiting

  • Universitätsklinikum Erlangen, Neurologische Klinik

    Erlangen 2929567, 91054
    Germany

    Site Not Available

  • Praxis Nervenstark

    Essen, 45257
    Germany

    Active - Recruiting

  • Zentrum für ambulante Neurologie / Praxis Knorn Landefeld Friedrich

    Essen, 45138
    Germany

    Active - Recruiting

  • Zentrum für ambulante Neurologie / Praxis Knorn Landefeld Friedrich

    Essen 2928810, 45138
    Germany

    Site Not Available

  • Praxis für Neurologie, Nervenheilkunde & Neurochirurgie

    Forchheim, 91301
    Germany

    Site Not Available

  • Praxis für Neurologie, Nervenheilkunde & Neurochirurgie

    Forchheim 2925910, 91301
    Germany

    Site Not Available

  • Varisano Klinikum Frankfurt Höchst GmbH

    Frankfurt, 65929
    Germany

    Active - Recruiting

  • Universitätsklinikum Freiburg, Klinik für Neurologie und Neurophysiologie

    Freiburg, 79106
    Germany

    Site Not Available

  • Universitätsklinikum Freiburg, Klinik für Neurologie und Neurophysiologie

    Freiburg im Breisgau, 79106
    Germany

    Active - Recruiting

  • Universitätsklinikum Freiburg, Klinik für Neurologie und Neurophysiologie

    Freiburg im Breisgau 2925177, 79106
    Germany

    Site Not Available

  • Praxis im Bahnhof

    Füssen, 87629
    Germany

    Active - Recruiting

  • Praxis im Bahnhof

    Füssen 2923507, 87629
    Germany

    Site Not Available

  • Universitätsklinikum Gießen und Marburg GmbH

    Giessen, 35392
    Germany

    Active - Recruiting

  • Neurologie & Psychiatrie Gladenbach - MS-Zentrum

    Gladenbach, 35075
    Germany

    Active - Recruiting

  • Neurologie & Psychiatrie Gladenbach - MS-Zentrum

    Gladenbach 2920229, 35075
    Germany

    Site Not Available

  • MVZ Bezirkskliniken Schwaben, Standort Günzburg

    Günzburg, 89312
    Germany

    Active - Recruiting

  • Krankenhaus Martha-Maria Halle-Doelau

    Halle, 06120
    Germany

    Active - Recruiting

  • Neurologische Praxis Eppendorf

    Hamburg, 20249
    Germany

    Active - Recruiting

  • Universiätsklinikum Hamburg-Eppendorf

    Hamburg, 20246
    Germany

    Active - Recruiting

  • Neurologische Praxis Eppendorf

    Hamburg 2911298, 20249
    Germany

    Site Not Available

  • Neurologische Praxis

    Hannover, 30171
    Germany

    Site Not Available

  • Neurologische Praxis

    Hanover, 30171
    Germany

    Active - Recruiting

  • Neurologische Praxis

    Hanover 2910831, 30171
    Germany

    Site Not Available

  • Oberhavel Kliniken GmbH, Klinik Hennigsdorf, Neurologie

    Hennigsdorf, 16761
    Germany

    Active - Recruiting

  • Oberhavel Kliniken GmbH, Klinik Hennigsdorf, Neurologie

    Hennigsdorf 2906331, 16761
    Germany

    Site Not Available

  • Praxis Dr. Hospely

    Herford, 32052
    Germany

    Active - Recruiting

  • Praxis Dr. Hospely

    Herford 2906121, 32052
    Germany

    Site Not Available

  • Haus- und Facharztzentrum Laucherttal / Alb

    Hettingen, 72513
    Germany

    Active - Recruiting

  • Haus- und Facharztzentrum Laucherttal / Alb

    Hettingen 2905215, 72513
    Germany

    Site Not Available

  • Klinikum Ibbenbüren gmbH

    Ibbenbueren, 49477
    Germany

    Active - Recruiting

  • Klinikum Ibbenbüren gmbH

    Ibbenbueren 2896817, 49477
    Germany

    Site Not Available

  • Klinikum Ibbenbüren gmbH

    Ibbenbüren, 49477
    Germany

    Site Not Available

  • Augustahospital Anholt;Neurologie

    Isselburg, 46419
    Germany

    Active - Recruiting

  • Augustahospital Anholt;Neurologie

    Isselburg 2895630, 46419
    Germany

    Site Not Available

  • Universitätsklinikum Jena, Klinik für Neurologie

    Jena, 07747
    Germany

    Active - Recruiting

  • Universitätsklinikum Jena, Klinik für Neurologie

    Jena 2895044, 07747
    Germany

    Site Not Available

  • NeuroMed Campus Neurologische Gemeinschaftspraxis am St. Elisabeth Krankenhaus

    Köln, 50935
    Germany

    Site Not Available

  • Arztpraxis Dr. med. Torsten Sühnel

    Leipzig, 04299
    Germany

    Active - Recruiting

  • Neurologische Praxis Dr. Ehrlich

    Leipzig, 04315
    Germany

    Active - Recruiting

  • Arztpraxis Dr. med. Torsten Sühnel

    Leipzig 2879139, 04299
    Germany

    Site Not Available

  • Neurologische Praxis Dr. Ehrlich

    Leipzig 2879139, 04315
    Germany

    Active - Recruiting

  • Neurologie im Ulrichshaus Magdeburg

    Magdeburg, 39104
    Germany

    Active - Recruiting

  • Universitätsklinikum Magdeburg

    Magdeburg, 39120
    Germany

    Active - Recruiting

  • Neurologie im Ulrichshaus Magdeburg

    Magdeburg 2874545, 39104
    Germany

    Active - Recruiting

  • Universitätsklinikum Magdeburg

    Magdeburg 2874545, 39120
    Germany

    Site Not Available

  • Neuroplus Dres. Lennart Thilmann/ Patrick Thilmann

    Mannheim, 68163
    Germany

    Active - Recruiting

  • Universitätsklinikum Mannheim

    Mannheim, 68167
    Germany

    Active - Recruiting

  • Neuroplus Dres. Lennart Thilmann/ Patrick Thilmann

    Mannheim 2873891, 68163
    Germany

    Site Not Available

  • Universitätsklinikum Mannheim

    Mannheim 2873891, 68167
    Germany

    Active - Recruiting

  • Universitätsklinikum Giessen und Marburg

    Marburg, 35043
    Germany

    Active - Recruiting

  • Universitätsklinikum Giessen und Marburg

    Marburg 2873759, 35043
    Germany

    Site Not Available

  • Praxis Dr. Leussink

    Meerbusch, 40667
    Germany

    Active - Recruiting

  • Praxis Dr. Leussink

    Meerbusch 2872504, 40667
    Germany

    Site Not Available

  • Neurologie am Preußenmuseum

    Minden, 32423
    Germany

    Active - Recruiting

  • Neurologie am Preußenmuseum

    Minden 2871039, 32423
    Germany

    Site Not Available

  • Neurologie München Nord

    München, 80939
    Germany

    Active - Recruiting

  • Praxis für Neurologie und Psychiatrie am Prinzregentenplatz

    München, 81675
    Germany

    Active - Recruiting

  • Neurologie München Nord

    München 2867711, 80939
    Germany

    Active - Recruiting

  • Praxis für Neurologie und Psychiatrie am Prinzregentenplatz

    München 2867711, 81675
    Germany

    Site Not Available

  • Neurologisch-psychiatrische Praxis im A4

    Neu - Ulm, 89231
    Germany

    Site Not Available

  • Neurologisch-psychiatrische Praxis im A4

    Neu-Ulm, 89231
    Germany

    Active - Recruiting

  • Neurologisch-psychiatrische Praxis im A4

    Neu-Ulm 2863941, 89231
    Germany

    Site Not Available

  • Praxis Dr. med. Bergmann

    Neuburg, 86633
    Germany

    Site Not Available

  • Praxis Dr. med. Bergmann

    Neuburg am Inn, 86633
    Germany

    Active - Recruiting

  • Praxis Dr. med. Bergmann

    Neuburg am Inn 2866075, 86633
    Germany

    Site Not Available

  • Gemeinschaftspraxis Uhlig und Windsheimer

    Nuremberg, 90419
    Germany

    Active - Recruiting

  • Neurologie Nürnberg-Eibach

    Nuremberg, 90451
    Germany

    Active - Recruiting

  • Neurologie Nürnberg-Eibach

    Nuremberg 2861650, 90451
    Germany

    Site Not Available

  • Neurologie Nürnberg-Eibach

    Nürnberg, 90451
    Germany

    Site Not Available

  • Neurologie an der Hase

    Osnabrück, 49074
    Germany

    Active - Recruiting

  • Neurologie an der Hase

    Osnabrück 2856883, 49074
    Germany

    Site Not Available

  • Facharztpraxis für Neurologie und Psychiatrie Dres Mattes/Stockert

    Pforzheim, 75172
    Germany

    Active - Recruiting

  • Facharztpraxis für Neurologie und Psychiatrie Dres Mattes/Stockert

    Pforzheim 2853969, 75172
    Germany

    Site Not Available

  • Neurologisches Studienzentrum Artland

    Quakenbrück, 49610
    Germany

    Active - Recruiting

  • Neurologisches Studienzentrum Artland

    Quakenbrück 2851523, 49610
    Germany

    Site Not Available

  • Gemeinschaftspraxis für Neurologie

    Regensburg, 93059
    Germany

    Active - Recruiting

  • Gemeinschaftspraxis für Neurologie

    Regensburg 2849483, 93059
    Germany

    Site Not Available

  • Praxis Dr. Stienker-Fisse

    Remscheid, 42853
    Germany

    Active - Recruiting

  • Praxis Dr. Stienker-Fisse

    Remscheid 2848273, 42853
    Germany

    Site Not Available

  • ZNS Südpfalz

    Rülzheim, 76761
    Germany

    Active - Recruiting

  • ZNS Südpfalz

    Rülzheim 2843146, 76761
    Germany

    Site Not Available

  • Neurologische Praxis Dr. Wagner

    Schwetzingen, 68723
    Germany

    Active - Recruiting

  • Neurologische Praxis Dr. Wagner

    Schwetzingen 2834240, 68723
    Germany

    Site Not Available

  • Gemeinschaftspraxis für Neurologie, Psychiatrie und Psychotherapie

    Siegen, 57072
    Germany

    Active - Recruiting

  • Praxis für Neurologie und Psychiatrie

    Siegen, 57076
    Germany

    Active - Recruiting

  • Gemeinschaftspraxis für Neurologie, Psychiatrie und Psychotherapie

    Siegen 2832495, 57072
    Germany

    Active - Recruiting

  • Praxis für Neurologie und Psychiatrie

    Siegen 2832495, 57076
    Germany

    Site Not Available

  • EMSA - Zentrum für Neurologie?/?Psychiatrie?/?Neuroradiologie

    Singen, 78224
    Germany

    Active - Recruiting

  • EMSA - Zentrum für Neurologie?/?Psychiatrie?/?Neuroradiologie

    Singen 2831924, 78224
    Germany

    Site Not Available

  • Praxis Dr. med. Max Deist und Michael Ernst ?Sinsheim

    Sinsheim, 74889
    Germany

    Active - Recruiting

  • Praxis Dr. med. Max Deist und Michael Ernst ?Sinsheim

    Sinsheim 2831872, 74889
    Germany

    Site Not Available

  • Gemeinschaftspraxis Dr. Wolfram von Pannwitz, MBA & Dr. med. Marie Perle Brinckmann

    Steglitz, 12163
    Germany

    Active - Recruiting

  • Gemeinschaftspraxis Dr. Wolfram von Pannwitz, MBA & Dr. med. Marie Perle Brinckmann

    Steglitz 2829109, 12163
    Germany

    Site Not Available

  • Neuropraxis Sotiriadis

    Stuttgart, 70176
    Germany

    Active - Recruiting

  • Neurozentrum Stuttgart Mitte Sophienstraße

    Stuttgart, 70178
    Germany

    Active - Recruiting

  • Praxis Dr. med. Andreas Kowalik, Arzt für Neurologie und Psychiatrie

    Stuttgart, 70174
    Germany

    Active - Recruiting

  • Neuropraxis Sotiriadis

    Stuttgart 2825297, 70176
    Germany

    Active - Recruiting

  • Neurozentrum Stuttgart Mitte Sophienstraße

    Stuttgart 2825297, 70178
    Germany

    Site Not Available

  • Praxis Dr. med. Andreas Kowalik, Arzt für Neurologie und Psychiatrie

    Stuttgart 2825297, 70174
    Germany

    Active - Recruiting

  • Sauerlandklinik Hachen

    Sundern, 59846
    Germany

    Active - Recruiting

  • Sauerlandklinik Hachen

    Sundern 2824655, 59846
    Germany

    Site Not Available

  • Universitätsklinikum Tübingen, Zentrum für Neurologie

    Tübingen, 72076
    Germany

    Active - Recruiting

  • Universitätsklinikum Tübingen, Zentrum für Neurologie

    Tübingen 2820860, 72076
    Germany

    Site Not Available

  • Nervenfachaerztliche Gemeinschaftspraxis Ulm

    Ulm, 89078
    Germany

    Active - Recruiting

  • Nervenfachaerztliche Gemeinschaftspraxis Ulm

    Ulm 2820256, 89078
    Germany

    Site Not Available

  • Neuropraxis München Süd

    Unterhaching, 82008
    Germany

    Active - Recruiting

  • Neuropraxis München Süd

    Unterhaching 2819465, 82008
    Germany

    Site Not Available

  • Praxis für Neurologie, Psychiatrie und Epileptologie

    Weil der Stadt, 71263
    Germany

    Active - Recruiting

  • Praxis für Neurologie, Psychiatrie und Epileptologie

    Weil der Stadt 2812625, 71263
    Germany

    Site Not Available

  • Praxis Dr. Michaela Krause

    Wolfratshausen, 82515
    Germany

    Active - Recruiting

  • Praxis Dr. Michaela Krause

    Wolfratshausen 2806768, 82515
    Germany

    Site Not Available

  • Heinrich-Braun-Krankenhaus Städtisches Klinikum

    Zwickau, 08060
    Germany

    Active - Recruiting

  • Heinrich-Braun-Krankenhaus Städtisches Klinikum

    Zwickau 2803560, 08060
    Germany

    Site Not Available

  • Dres. Beckmann / Schlüter

    Öhringen, 74613
    Germany

    Active - Recruiting

  • Dres. Beckmann / Schlüter

    Öhringen 2857565, 74613
    Germany

    Site Not Available

  • Inselspital-Universitaetsspital Bern

    Bern, 3010
    Switzerland

    Active - Recruiting

  • Inselspital-Universitaetsspital Bern

    Bern 2661552, 3010
    Switzerland

    Site Not Available

  • Bellevue Medical Grop AG

    Zurich, 8001
    Switzerland

    Active - Recruiting

  • Bellevue Medical Grop AG

    Zurich 2657896, 8001
    Switzerland

    Site Not Available

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