A Study to Investigate Effects of Ocrelizumab Treatment on Neurofilament Light Chain (NfL) Levels and Participant Satisfaction in Participants With Multiple Sclerosis (MS)

Last updated: April 8, 2025
Sponsor: Hoffmann-La Roche
Overall Status: Active - Recruiting

Phase

N/A

Condition

Multiple Sclerosis

Memory Loss

Scar Tissue

Treatment

Ocrelizumab

Clinical Study ID

NCT06780150
ML45551
  • Ages > 18
  • All Genders

Study Summary

The main purpose of the study is to evaluate participant satisfaction after administration of ocrelizumab subcutaneous (SC) after 12 months using the therapy administration satisfaction questionnaire subcutaneous (TASQ-SC).

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Diagnosis of MS

  • RMS and PPMS participants diagnosed according to the McDonald criteria of 2017

  • First treatment during the course of MS therapy with ocrelizumab SC according to thelocal prescribing information, regardless of the reason for starting treatment withocrelizumab

Exclusion

Exclusion Criteria:

  • Participation in interventional studies investigating DMTs for MS

  • Prior or simultaneous participation in CONFIDENCE or MoOzaRt (ISRCTN55332718) noninterventional study (NIS) at the same study site

  • Prior treatment with rituximab (MabThera®) or ublituximab (Briumvi®)

  • Severe psychiatric disability

  • Pregnant and/or breastfeeding women

Study Design

Total Participants: 349
Treatment Group(s): 1
Primary Treatment: Ocrelizumab
Phase:
Study Start date:
September 26, 2024
Estimated Completion Date:
September 26, 2026

Connect with a study center

  • Uniklinik RWTH Aachen

    Aachen, 52074
    Germany

    Active - Recruiting

  • Neuropraxis im Stadtpalais Dres. Ulzheimer/Herröder/Wessig GbR

    Aschaffenburg, 63739
    Germany

    Active - Recruiting

  • Neurologische Praxis - Kallmann Neurologie - mszb

    Bamberg, 96052
    Germany

    Active - Recruiting

  • Neurologisches Facharztzentrum Berlin am Sankt Gertrauden-Krankenhaus

    Berlin, 10713
    Germany

    Active - Recruiting

  • Praxis Dr. Said Masri

    Berlin, 12099
    Germany

    Active - Recruiting

  • Gemeinschaftspraxis Dr. Wolfram von Pannwitz, MBA & Dr. med. Marie Perle Brinckmann

    Berlin-Steglitz, 12163
    Germany

    Active - Recruiting

  • St. Josef-Hospital

    Bochum, 44791
    Germany

    Active - Recruiting

  • Neuropraxis Celle: Praxis für Neurologie & Psychatrie

    Celle, 29223
    Germany

    Active - Recruiting

  • Praxisgemeinschaft Dres. Sylke Domke und Vasil Gjaurov

    Chemnitz, 09117
    Germany

    Active - Recruiting

  • Gemeinschaftspraxis für Neurologie

    Düsseldorf, 40211
    Germany

    Active - Recruiting

  • Universitätsklinikum Düsseldorf

    Düsseldorf, 40225
    Germany

    Active - Recruiting

  • Gemeinschaftspraxis für Neurologie und Psychiatrie, Psychotherapie

    Eltville, 65343
    Germany

    Active - Recruiting

  • NeuroCentrum Odenwald

    Erbach/Odenwald, 64711
    Germany

    Active - Recruiting

  • Universitätsklinikum Erlangen, Neurologische Klinik

    Erlangen, 91054
    Germany

    Active - Recruiting

  • Universitätsklinikum Freiburg, Klinik für Neurologie und Neurophysiologie

    Freiburg, 79106
    Germany

    Active - Recruiting

  • Neurologie & Psychiatrie Gladenbach - MS-Zentrum

    Gladenbach, 35075
    Germany

    Active - Recruiting

  • Neurologische Praxis Eppendorf

    Hamburg, 20249
    Germany

    Active - Recruiting

  • Neurologische Praxis

    Hannover, 30171
    Germany

    Active - Recruiting

  • Oberhavel Kliniken GmbH, Klinik Hennigsdorf, Neurologie

    Hennigsdorf, 16761
    Germany

    Active - Recruiting

  • Praxis Dr. Hospely

    Herford, 32052
    Germany

    Active - Recruiting

  • Klinikum Ibbenbüren gmbH

    Ibbenbüren, 49477
    Germany

    Active - Recruiting

  • Universitätsklinikum Jena, Klinik für Neurologie

    Jena, 07747
    Germany

    Active - Recruiting

  • NeuroMed Campus Neurologische Gemeinschaftspraxis am St. Elisabeth Krankenhaus

    Köln, 50935
    Germany

    Active - Recruiting

  • Neurologische Praxis Dr. Ehrlich

    Leipzig, 04315
    Germany

    Active - Recruiting

  • Neurologie im Ulrichshaus Magdeburg

    Magdeburg, 39104
    Germany

    Active - Recruiting

  • Neuroplus Dres. Lennart Thilmann/ Patrick Thilmann

    Mannheim, 68163
    Germany

    Active - Recruiting

  • Universitätsklinikum Mannheim

    Mannheim, 68167
    Germany

    Active - Recruiting

  • Praxis Dr. Leussink

    Meerbusch, 40667
    Germany

    Active - Recruiting

  • Neurologie am Preußenmuseum

    Minden, 32423
    Germany

    Active - Recruiting

  • Neurologie München Nord

    München, 80939
    Germany

    Active - Recruiting

  • Praxis für Neurologie und Psychiatrie am Prinzregentenplatz

    München, 81675
    Germany

    Active - Recruiting

  • Neurologisch-psychiatrische Praxis im A4

    Neu - Ulm, 89231
    Germany

    Active - Recruiting

  • Praxis Dr. med. Bergmann

    Neuburg, 86633
    Germany

    Active - Recruiting

  • Neurologie Nürnberg-Eibach

    Nürnberg, 90451
    Germany

    Active - Recruiting

  • Facharztpraxis für Neurologie und Psychiatrie Dres Mattes/Stockert

    Pforzheim, 75172
    Germany

    Active - Recruiting

  • Neurologisches Studienzentrum Artland

    Quakenbrück, 49610
    Germany

    Active - Recruiting

  • Gemeinschaftspraxis für Neurologie

    Regensburg, 93059
    Germany

    Active - Recruiting

  • Praxis Dr. Stienker-Fisse

    Remscheid, 42853
    Germany

    Active - Recruiting

  • Neurologische Praxis Dr. Wagner

    Schwetzingen, 68723
    Germany

    Active - Recruiting

  • Praxis für Neurologie und Psychiatrie

    Siegen, 57076
    Germany

    Active - Recruiting

  • EMSA - Zentrum für Neurologie?/?Psychiatrie?/?Neuroradiologie

    Singen, 78224
    Germany

    Active - Recruiting

  • Praxis Dr. med. Andreas Kowalik, Arzt für Neurologie und Psychiatrie

    Stuttgart, 70174
    Germany

    Active - Recruiting

  • Universitätsklinikum Tübingen, Zentrum für Neurologie

    Tübingen, 72076
    Germany

    Active - Recruiting

  • Nervenfachaerztliche Gemeinschaftspraxis Ulm

    Ulm, 89078
    Germany

    Active - Recruiting

  • Neuropraxis München Süd

    Unterhaching, 82008
    Germany

    Active - Recruiting

  • Praxis für Neurologie, Psychiatrie und Epileptologie

    Weil der Stadt, 71263
    Germany

    Active - Recruiting

  • Praxis Dr. Michaela Krause

    Wolfratshausen, 82515
    Germany

    Active - Recruiting

  • Heinrich-Braun-Krankenhaus Städtisches Klinikum

    Zwickau, 08060
    Germany

    Active - Recruiting

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