Ultra Processed Foods Consumption and Impact in Rheumatic Diseases.

Last updated: April 10, 2025
Sponsor: Hospices Civils de Lyon
Overall Status: Active - Recruiting

Phase

N/A

Condition

Osteoarthritis

Collagen Vascular Diseases

Lupus

Treatment

Dietary Questionnaire

Evaluation of disease activity (DAS-28, ASDAS, EVA, number of swollen joints, number of painful joint, nocturnal pain, morning stiffness)

Clinical Study ID

NCT06776965
69HCL24_0947
2024-A02327-40
  • Ages > 18
  • All Genders

Study Summary

Ultra-processed foods (UPF) represent one of the mainstays of today's diet. They are defined by the NOVA classification system. It was demonstrated that UPF consumption was associated with activity of inflammatory bowel diseases with underlying mechanisms not fully identified yet. It is suspected that UPF constituents could modify the gut microbiota, increase intestinal barrier permeability and directly engage immune surveillance systems, effects that could individually or synergistically increase the risk of immunomediated diseases. As some pathophysiological mechanisms are shared among IBD and rheumatic diseases, we have wondered if UPF consumption could be associated with increased risk of rheumatic disease and/or with their activity.

Our primary aim will be to study the pattern of UPF consumption in patients with rheumatic diseases. Our secondary objectives will be to study the activity of diseases according to UPF consumption.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Age > 18 years

  • chronic rheumatic disease (Rheumatoid arthritis, spondyloarthritis, osteoarthritis)

  • ability to perform questionnaires

Exclusion

Exclusion Criteria:

  • Judicial protection measure

  • Refusal to participate in the study

  • Suffering from 2 rheumatic disease simultaneously

Study Design

Total Participants: 240
Treatment Group(s): 2
Primary Treatment: Dietary Questionnaire
Phase:
Study Start date:
March 31, 2025
Estimated Completion Date:
November 30, 2026

Connect with a study center

  • Edouard Herriot Hospital

    Lyon, 69003
    France

    Active - Recruiting

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