Study to Assess Change in Disease Activity of Risankizumab Treatment in Adult Participants With Moderate to Severe Ulcerative Colitis

Last updated: May 11, 2026
Sponsor: AbbVie
Overall Status: Active - Recruiting

Phase

N/A

Condition

Ulcerative Colitis

Inflammatory Bowel Disease

Ulcers

Treatment

N/A

Clinical Study ID

NCT06764706
P25-544
  • Ages > 18
  • All Genders

Study Summary

Ulcerative colitis (UC) is a type of inflammatory bowel disease that causes inflammation and bleeding from the lining of the rectum and colon (large intestine). This study will assess the change in disease activity of risankizumab treatment in adult participants with moderate to severe UC in real-world clinical practice.

Risankizumab is an approved drug for treating participants with ulcerative colitis. Approximately 200 participants who are prescribed risankizumab by their physician in accordance with local label will be enrolled in approximately multiple sites across Germany and Austria.

Participants will receive risankizumab as prescribed by their physician according to their routine clinical practice and local label. Participants will be followed for up to 52 weeks.

There is expected to be no additional burden for participants in this trial. Participants will attend regular visits during the study at a hospital or clinic according to their routine clinical practice.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Participants with an endoscopically confirmed diagnosis of moderate to severeulcerative colitis.

  • Participants initiating risankizumab at the investigator's discretion as part oftheir routine clinical care; the decision to administer risankizumab must be madeprior to and independent of documentation for the study and according to theapproved local label.

Exclusion

Exclusion Criteria:

  • Participants previously exposed risankizumab

  • Participants who are currently participating in interventional research (notincluding noninterventional studies, post-marketing observational study (PMOS), orregistry participation).

Study Design

Total Participants: 200
Study Start date:
February 27, 2025
Estimated Completion Date:
July 31, 2028

Connect with a study center

  • Universitaetsklinikum Heidelberg /ID# 275906

    Heidelberg, Baden-Wurttemberg 69120
    Germany

    Active - Recruiting

  • Universitaetsklinikum Heidelberg /ID# 275906

    Heidelberg 2907911, Baden-Wurttemberg 2953481 69120
    Germany

    Site Not Available

  • Klinikum Ernst Von Bergmann /ID# 278268

    Potsdam, Brandenburg 14467
    Germany

    Active - Recruiting

  • Klinikum Ernst Von Bergmann /ID# 278268

    Potsdam 2852458, Brandenburg 2945356 14467
    Germany

    Site Not Available

  • Private Practice - Dr. Kempelmann /ID# 275726

    Tostedt, Free and Hanseatic City of Hamburg 21255
    Germany

    Active - Recruiting

  • Gastroenterologische Schwerpunktpraxis /ID# 276701

    Hanover, Lower Saxony 30449
    Germany

    Active - Recruiting

  • Gastroenterologische Schwerpunktpraxis /ID# 276701

    Hanover 2910831, Lower Saxony 2862926 30449
    Germany

    Site Not Available

  • Medizinisches Versorgungszentrum Ahaus /ID# 280966

    Ahaus, North Rhine-Westphalia 48683
    Germany

    Active - Recruiting

  • Gastropraxis Bochum /ID# 281375

    Bochum, North Rhine-Westphalia 44787
    Germany

    Active - Recruiting

  • Katholisches Klinikum Bochum gGmbH /ID# 279486

    Bochum, North Rhine-Westphalia 44791
    Germany

    Active - Recruiting

  • Evangelisches Krankenhaus Kalk /ID# 276414

    Cologne, North Rhine-Westphalia 51103
    Germany

    Active - Recruiting

  • Dres. Kamp & Partner /ID# 275904

    Minden, North Rhine-Westphalia 32423
    Germany

    Active - Recruiting

  • Gemeinschaftspraxis Innere Medizin /ID# 280068

    Witten, North Rhine-Westphalia 58445
    Germany

    Active - Recruiting

  • Medizinisches Versorgungszentrum Ahaus /ID# 280966

    Ahaus 2959279, North Rhine-Westphalia 2861876 48683
    Germany

    Site Not Available

  • Gastropraxis Bochum /ID# 281375

    Bochum 2947416, North Rhine-Westphalia 2861876 44787
    Germany

    Site Not Available

  • Katholisches Klinikum Bochum gGmbH /ID# 279486

    Bochum 2947416, North Rhine-Westphalia 2861876 44791
    Germany

    Active - Recruiting

  • Evangelisches Krankenhaus Kalk /ID# 276414

    Cologne 2886242, North Rhine-Westphalia 2861876 51103
    Germany

    Site Not Available

  • Dres. Kamp & Partner /ID# 275904

    Minden 2871039, North Rhine-Westphalia 2861876 32423
    Germany

    Site Not Available

  • Gemeinschaftspraxis Innere Medizin /ID# 280068

    Witten 2807363, North Rhine-Westphalia 2861876 58445
    Germany

    Site Not Available

  • Gastroenterologische Gemeinschaftspraxis Im Loehr-Center Koblenz /ID# 275943

    Koblenz, Rhineland-Palatinate 56068
    Germany

    Active - Recruiting

  • Gastroenterologische Schwerpunkt Praxis /ID# 279856

    Ludwigshafen am Rhein, Rhineland-Palatinate 67071
    Germany

    Active - Recruiting

  • Gastroenterologische Gemeinschaftspraxis Im Loehr-Center Koblenz /ID# 275943

    Koblenz 2886946, Rhineland-Palatinate 2847618 56068
    Germany

    Site Not Available

  • Gastroenterologische Schwerpunkt Praxis /ID# 279856

    Ludwigshafen am Rhein 2875376, Rhineland-Palatinate 2847618 67071
    Germany

    Site Not Available

  • Studiengesellschaft BSF Unternehmergesellschaft /ID# 275905

    Halle (Saale), Sachsen-Anhalt 06108
    Germany

    Site Not Available

  • Private Practice - Dr. Johannes Janschek /ID# 275877

    Dresden, Saxony 01309
    Germany

    Active - Recruiting

  • Gesellschaft für klinische Studien /ID# 275867

    Leipzig, Saxony 04105
    Germany

    Active - Recruiting

  • Universitaetsklinikum Leipzig /ID# 276779

    Leipzig, Saxony 04103
    Germany

    Active - Recruiting

  • Private Practice - Dr. Johannes Janschek /ID# 275877

    Dresden 2935022, Saxony 2842566 01309
    Germany

    Site Not Available

  • Gesellschaft für klinische Studien /ID# 275867

    Leipzig 2879139, Saxony 2842566 04105
    Germany

    Active - Recruiting

  • Universitaetsklinikum Leipzig /ID# 276779

    Leipzig 2879139, Saxony 2842566 04103
    Germany

    Site Not Available

  • Private Practice - Dr. Thomas Zeisler /ID# 277933

    Halle, Saxony-Anhalt 06108
    Germany

    Active - Recruiting

  • Studiengesellschaft BSF Unternehmergesellschaft /ID# 275905

    Halle, Saxony-Anhalt 06108
    Germany

    Active - Recruiting

  • Praxisgemeinschaft Jerichow Schulze /ID# 275911

    Jerichow, Saxony-Anhalt 39319
    Germany

    Active - Recruiting

  • Private Practice - Dr. Jaqueline Schumann /ID# 276126

    Teuchern, Saxony-Anhalt 06682
    Germany

    Active - Recruiting

  • Private Practice - Dr. Thomas Zeisler /ID# 277933

    Halle 2911522, Saxony-Anhalt 2842565 06108
    Germany

    Active - Recruiting

  • Studiengesellschaft BSF Unternehmergesellschaft /ID# 275905

    Halle 2911522, Saxony-Anhalt 2842565 06108
    Germany

    Site Not Available

  • Praxisgemeinschaft Jerichow Schulze /ID# 275911

    Jerichow 2895008, Saxony-Anhalt 2842565 39319
    Germany

    Site Not Available

  • Private Practice - Dr. Jaqueline Schumann /ID# 276126

    Teuchern 2823355, Saxony-Anhalt 2842565 06682
    Germany

    Site Not Available

  • Gemeinschaftspraxis im Medicum /ID# 275933

    Altenholz, Schleswig-Holstein 24161
    Germany

    Active - Recruiting

  • Praxis Jessen/Grimm /ID# 275933

    Altenholz, Schleswig-Holstein 24161
    Germany

    Active - Recruiting

  • Praxis S. Tetzlaff /ID# 275882

    Buedelsdorf, Schleswig-Holstein 24782
    Germany

    Active - Recruiting

  • Praxis S. Tetzlaff /ID# 275882

    Büdelsdorf, Schleswig-Holstein 24782
    Germany

    Site Not Available

  • Praxis Dr. Guenther-Tritsch /ID# 275886

    Geesthacht, Schleswig-Holstein 21502
    Germany

    Active - Recruiting

  • Diabetologie Dithmarschen /ID# 281104

    Heide, Schleswig-Holstein 25746
    Germany

    Active - Recruiting

  • Private Practice - Dr. Thormann & Dr. Bethge /ID# 275931

    Kiel, Schleswig-Holstein 24105
    Germany

    Active - Recruiting

  • Praxis fuer Gastroenterologie /ID# 275903

    Lübeck, Schleswig-Holstein 23560
    Germany

    Active - Recruiting

  • Fek - Friedrich-Ebert-Krankenhaus Neumünster /ID# 276105

    Neumünster, Schleswig-Holstein 24534
    Germany

    Active - Recruiting

  • Gemeinschaftspraxis im Medicum /ID# 275933

    Altenholz 2957588, Schleswig-Holstein 2838632 24161
    Germany

    Site Not Available

  • Praxis S. Tetzlaff /ID# 275882

    Buedelsdorf 2942093, Schleswig-Holstein 2838632 24782
    Germany

    Site Not Available

  • Praxis Dr. Guenther-Tritsch /ID# 275886

    Geesthacht 2922102, Schleswig-Holstein 2838632 21502
    Germany

    Site Not Available

  • Diabetologie Dithmarschen /ID# 281104

    Heide 2908032, Schleswig-Holstein 2838632 25746
    Germany

    Site Not Available

  • Private Practice - Dr. Thormann & Dr. Bethge /ID# 275931

    Kiel 2891122, Schleswig-Holstein 2838632 24105
    Germany

    Site Not Available

  • Praxis fuer Gastroenterologie /ID# 275903

    Lübeck 2875601, Schleswig-Holstein 2838632 23560
    Germany

    Site Not Available

  • Fek - Friedrich-Ebert-Krankenhaus Neumünster /ID# 276105

    Neumünster 2864475, Schleswig-Holstein 2838632 24534
    Germany

    Site Not Available

  • Dr. Jack Peter-Stein /ID# 276815

    Jena, Thuringia 07743
    Germany

    Active - Recruiting

  • Tumorzentrum Nordthuringen Medizinisches Versorgungszentrum /ID# 280072

    Nordhausen, Thuringia 99734
    Germany

    Active - Recruiting

  • Dr. Jack Peter-Stein /ID# 276815

    Jena 2895044, Thuringia 2822542 07743
    Germany

    Site Not Available

  • Tumorzentrum Nordthuringen Medizinisches Versorgungszentrum /ID# 280072

    Nordhausen 2861982, Thuringia 2822542 99734
    Germany

    Site Not Available

  • Praxis Heil & Mueller /ID# 275927

    Andernach, 56626
    Germany

    Active - Recruiting

  • Praxis Heil & Mueller /ID# 275927

    Andernach 2956206, 56626
    Germany

    Site Not Available

  • Charite Universitaetsmedizin Berlin - Campus Mitte /ID# 275884

    Berlin, 10117
    Germany

    Active - Recruiting

  • Dres. Schick/Wesenberg /ID# 275878

    Berlin, 10437
    Germany

    Active - Recruiting

  • Drk Kliniken Berlin - Köpenick /ID# 276277

    Berlin, 12559
    Germany

    Active - Recruiting

  • Facharztpraxis fur Gastroenterologie Karlshorst /ID# 277966

    Berlin, 10318
    Germany

    Active - Recruiting

  • Facharztpraxis für Gastroenterologie Karlshorst /ID# 277966

    Berlin, 10318
    Germany

    Site Not Available

  • Gastro Studien GbR /ID# 275920

    Berlin, 10825
    Germany

    Active - Recruiting

  • Gastroenterologie im Mühlenbergviertel /ID# 275883

    Berlin, 10409
    Germany

    Active - Recruiting

  • Krankenhaus Waldfriede /ID# 275913

    Berlin, 14163
    Germany

    Active - Recruiting

  • Praxis Dr. Soellenboehmer /ID# 276183

    Berlin, 14052
    Germany

    Active - Recruiting

  • Praxis Dr. Spitz /ID# 275912

    Berlin, 14163
    Germany

    Active - Recruiting

  • Private Practice - Dr. Jeannette Schwenzer & Dr. Sven Gruengreiff /ID# 276089

    Berlin, 12683
    Germany

    Active - Recruiting

  • Private Practice- Dr. Andreas Horn /ID# 281448

    Berlin, 10369
    Germany

    Active - Recruiting

  • Charite Universitaetsmedizin Berlin - Campus Mitte /ID# 275884

    Berlin 2950159, 10117
    Germany

    Active - Recruiting

  • Dres. Schick/Wesenberg /ID# 275878

    Berlin 2950159, 10437
    Germany

    Active - Recruiting

  • Drk Kliniken Berlin - Köpenick /ID# 276277

    Berlin 2950159, 12559
    Germany

    Active - Recruiting

  • Facharztpraxis fur Gastroenterologie Karlshorst /ID# 277966

    Berlin 2950159, 10318
    Germany

    Active - Recruiting

  • Gastro Studien GbR /ID# 275920

    Berlin 2950159, 10825
    Germany

    Active - Recruiting

  • Gastroenterologie im Mühlenbergviertel /ID# 275883

    Berlin 2950159, 10409
    Germany

    Active - Recruiting

  • Krankenhaus Waldfriede /ID# 275913

    Berlin 2950159, 14163
    Germany

    Active - Recruiting

  • Praxis Dr. Soellenboehmer /ID# 276183

    Berlin 2950159, 14052
    Germany

    Active - Recruiting

  • Praxis Dr. Spitz /ID# 275912

    Berlin 2950159, 14163
    Germany

    Active - Recruiting

  • Private Practice - Dr. Jeannette Schwenzer & Dr. Sven Gruengreiff /ID# 276089

    Berlin 2950159, 12683
    Germany

    Active - Recruiting

  • Private Practice- Dr. Andreas Horn /ID# 281448

    Berlin 2950159, 10369
    Germany

    Site Not Available

  • Dr. Janschek /ID# 275877

    Dresden, 01309
    Germany

    Site Not Available

  • Universitaetsklinikum Duesseldorf /ID# 280409

    Düsseldorf, 40225
    Germany

    Active - Recruiting

  • Universitaetsklinikum Duesseldorf /ID# 280409

    Düsseldorf 2934246, 40225
    Germany

    Site Not Available

  • Dres. Bauer/Doerflinger /ID# 276093

    Freiburg im Breisgau, 79102
    Germany

    Active - Recruiting

  • Dres. Bauer/Doerflinger /ID# 276093

    Freiburg im Breisgau 2925177, 79102
    Germany

    Site Not Available

  • Gastroenterologie Rahlstedt /ID# 276408

    Hamburg, 22143
    Germany

    Active - Recruiting

  • Private Practice - Dr. Matthias Eichler /ID# 275875

    Hamburg, 22041
    Germany

    Active - Recruiting

  • Gastroenterologie Rahlstedt /ID# 276408

    Hamburg 2911298, 22143
    Germany

    Site Not Available

  • Private Practice - Dr. Matthias Eichler /ID# 275875

    Hamburg 2911298, 22041
    Germany

    Active - Recruiting

  • GSGH Gastroenterologische Studiengesellschaft Herne GbR /ID# 275874

    Herne, 44623
    Germany

    Active - Recruiting

  • GSGH Gastroenterologische Studiengesellschaft Herne GbR /ID# 275874

    Herne 2905891, 44623
    Germany

    Site Not Available

  • Gastroenterologe am Ettlinger Tor /ID# 279854

    Karlsruhe, 76133
    Germany

    Active - Recruiting

  • Gastroenterologe am Ettlinger Tor /ID# 279854

    Karlsruhe 2892794, 76133
    Germany

    Site Not Available

  • Dres. Breitschwerdt/Glas/Gurtler /ID# 276057

    Leipzig, 04107
    Germany

    Active - Recruiting

  • Dres. Breitschwerdt/Glas/Gurtler /ID# 276057

    Leipzig 2879139, 04107
    Germany

    Active - Recruiting

  • MVZ Gastroenterologie Leverkusen /ID# 275901

    Leverkusen, 51375
    Germany

    Active - Recruiting

  • MVZ Gastroenterologie Leverkusen /ID# 275901

    Leverkusen 2878234, 51375
    Germany

    Site Not Available

  • Gastropraxis Magdeburg /ID# 275885

    Magdeburg, 39104
    Germany

    Active - Recruiting

  • Gastropraxis Magdeburg /ID# 275885

    Magdeburg 2874545, 39104
    Germany

    Site Not Available

  • Bettenworth & Partner /ID# 275900

    Münster, 48149
    Germany

    Active - Recruiting

  • Bettenworth & Partner /ID# 275900

    Münster 2867543, 48149
    Germany

    Site Not Available

  • Pc Docs /Id# 275876

    Pirmasens, 66953
    Germany

    Active - Recruiting

  • Pc Docs /Id# 275876

    Pirmasens 2853574, 66953
    Germany

    Site Not Available

  • Praxis fuer Gastroenterologie /ID# 275946

    Schwerin, 19057
    Germany

    Active - Recruiting

  • Praxis fuer Gastroenterologie /ID# 275946

    Schwerin 2834282, 19057
    Germany

    Site Not Available

  • Dres. Rehbehn/Skusa /ID# 276090

    Solingen, 42651
    Germany

    Active - Recruiting

  • Dres. Rehbehn/Skusa /ID# 276090

    Solingen 2831580, 42651
    Germany

    Site Not Available

  • Praxis Dr. Kempelmann /ID# 275726

    Tostedt, 21255
    Germany

    Active - Recruiting

  • Private Practice - Dr. Markus Braunfels /ID# 277129

    Wesseling, 50389
    Germany

    Active - Recruiting

  • Private Practice - Dr. Markus Braunfels /ID# 277129

    Wesseling 2810612, 50389
    Germany

    Site Not Available

  • Dr. Schirin-Sokhan /ID# 276982

    Würselen, 52146
    Germany

    Active - Recruiting

  • Dr. Schirin-Sokhan /ID# 276982

    Würselen 2805644, 52146
    Germany

    Site Not Available

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