A Study Evaluating the Efficacy, Safety, Pharmacokinetics and Pharmacodynamics of AUR 109 in Patients with Colorectal, Ovarian, and Renal Cancers

Inclusion Criteria:

• Provide signed and dated informed consent and agree to comply with all study relatedactivities.

• Male or female patients aged ≥ 18 years.

• Pathological diagnosis of adenocarcinoma of colorectal origin, epithelial ovariancancer (ovarian cancer term also includes fallopian tube cancer as well as primaryperitoneal cancer), or renal cell carcinoma of the kidney.

• Patients must have received at least two lines of systemic therapy and should haveexhausted all available local therapies. At a minimum, for each of the respectivecancer types, patients should have received the following:

Colorectal Cancer - Previous treatment should include 5-FU based treatments, oxaliplatin based treatments, irinotecan-based treatments, IV VEGF inhibitors, IV EGFR antibodies (for KRAS wildtype), PD-1 antibodies for known MSI-H positive tumors, regorafenib and lonsurf, anti-HER2 agents (e.g., FDA approved Tucatinib and Trastuzumab combination, where available) for HER2 amplified colorectal cancer, unless any of these are not available locally or prohibitive for the patient financially or if the patient is not eligible for these or if the patient has refused these.

Ovarian cancer (also includes fallopian tube cancer and primary peritoneal cancer) - Tumor must be platinum refractory, defined as treatment free interval of < 6 months from the last platinum-based regimen. In addition, patient should have received topotecan, gemcitabine, liposomal doxorubicin, bevacizumab and PARP inhibitors (for BRCA mutants), mirvetuximab for folate receptor alpha amplified ovarian cancer, unless any of these are not available locally or prohibitive for the patient financially or if the patient is not eligible for these or if the patient has refused these.

Renal Cell Carcinoma - Patient should have received an oral VEGF inhibitor and PD-1/PD-L1 inhibitors, unless any of these are not available locally or prohibitive for the patient financially or if the patient is not eligible for these or if the patient has refused these.

• Eastern Cooperative Oncology Group (ECOG) Performance status of 0 or 1 (Patientswith disease related ECOG 2 are allowed, in addition to ECOG 0 and 1).

• Acceptable bone marrow function as described below:

ANC ≥ 1200/μL (without WBC growth factor support) Platelet count ≥ 90,000/μL without transfusion support Hemoglobin ≥ 9 g/dL (Transfusion is allowed to achieve this Hb)

• Acceptable organ function as described below:

Total Bilirubin ≤ 1.2 x ULN AST (SGOT) ≤ 3 x ULN (≤ 5 × ULN if known liver metastases) ALT (SGPT) ≤ 3 x ULN (≤ 5 × ULN if known liver metastases) Creatinine clearance (CrCl) ≥ 30 mL/min (either measured or estimated by the Cockcroft- Gault formula) [Cockcroft-Gault formula for estimated creatinine clearance (eCrCl) = (140 - Age) × Weight (kg) × (0.85 if Female) / (72 × serum creatinine (mg/dL))] Albumin ≥ 3.0 g/dL

• Ability to swallow and retain oral medications.

• Negative serum pregnancy test in women of childbearing potential (WOCBP).

• Women of childbearing potential and men who partner with such a woman ofchildbearing potential must agree to use one or more of highly effective method(s)for contraception for the duration of the study, i.e., through 28-day follow upvisit, after discontinuation of study drug(s).

• Evidence of measurable disease per RECIST, v1.1 for solid tumors. Measurable diseasefor solid tumors is defined as at least one lesion that can be accurately measuredin at least 1 dimension with a minimum size of 10 mm for non-nodal lesions or 15 mmin short axis for nodal lesions.

Exclusion Criteria:

• Patients without any wild type allele (Such as *28/*28, *37/*37 or *37/*28 variants)genotypes for UGT1A1.

• Systemic anti-cancer therapy, such as chemotherapy, biological therapy, orImmunomodulatory drug therapy, received within the past 28 days or 5 half-lives,whichever is longer, from the Cycle 1 Day 1 of the study.

• Presence of an acute or chronic toxicity resulting from prior anti-cancer treatment,with the exception of alopecia or nail changes, that has not resolved to Grade ≤ 1,as determined by NCI CTCAE v 5.0.

• Definitive Radiotherapy within the last 21 days of Cycle 1 Day 1 (limited fieldpalliative radiation is allowed and no restrictions during the screening period orduring the trial).

• Use of any investigational agent within 28 days or 5 half-lives (whichever islonger) prior to Cycle 1 Day 1.

• Known symptomatic or untreated or recently treated (≤ 6 months of screening) centralnervous system (CNS) metastases. Patients with previously treated (> 6 months ofscreening) and are now stable and asymptomatic, from CNS perspective, are allowed.

• Major surgery ≤ 28 days from Cycle 1 Day 1 (major surgery is defined as a procedurerequiring general anesthesia).

• Known to be human immunodeficiency virus (HIV) positive or have an acquiredimmunodeficiency syndrome-related illness.

• Known active or chronic hepatitis B or hepatitis C infection.

• Uncontrolled congestive heart failure (New York Heart Association [NYHA] Class 2-4),angina, myocardial infarction, cerebrovascular accident, coronary/peripheral arterybypass graft surgery, or transient ischemic attack, or pulmonary embolism within 3months prior to Cycle 1 Day 1.

• Left Ventricular Ejection Fraction (LVEF) < 50% at screening.

• Ongoing cardiac dysrhythmias requiring treatment of any grade or treatment ofcardiac dysrhythmias in past 3 months, before Cycle 1 Day 1.

• The QTcF (corrected QT interval Fridericia method) value in the screening ECG > 460 ms in both males and females.

• Previous or concomitant additional malignancy, except for basal-cell or squamouscell carcinoma of the skin or carcinoma-in-situ of the uterine cervix; patients withother malignancies are eligible if they have remained disease free for at least 2years prior to trial entry and in the opinion of the investigator deemed to have alow likelihood of recurrence.

• Pregnant or lactating women.

• Any clinically significant medical, psychiatric, or social condition; or laboratoryabnormality that may increase the risk of trial participation or may interfere withthe informed consent process and/or with compliance with the requirements of thetrial or may interfere with the interpretation of the trial results and, in theInvestigator's opinion, would make the patient inappropriate for entry into thistrial.

• Patients who require concomitant administration of drugs which have a high risk ofprolonging QT interval.

• Availability of any therapeutic options approved locally.