Prospective, Multicenter, Single-Arm Observational Study to Confirm the Safety and Clinical Performance of the Oscar Peripheral Multifunctional Catheter for the Dilatation of Lesions in the Femoral, Popliteal and Infrapopliteal Arteries (BIO-OSCAR First)

Inclusion Criteria:

1. Subject ≥18 years old

2. Subject has provided written informed consent

3. Subject has Rutherford classification 2 to 6

4. Reference vessel diameter ≥2 and ≤7 mm

5. Target lesion(s) has stenosis >70% by visual assessment

6. Multiple consecutive single lesions with a healthy segment(s) of ≤ 3cm in-betweenwill be considered one lesion. Above the knee (ATK) group:

7. Target lesions located in the superficial femoral artery or popliteal arteries (above the tibial plateau)

8. At least one below-knee artery patent to the ankle

9. Successful treatment of inflow iliac stenosis to the target lesion. Inflow lesionstenosis can be treated during the same procedure as per local standard of care. Theinflow lesion(s) must be treated first, prior to consideration of treatment of thetarget lesion. Subject can be enrolled if the inflow lesion(s) are treated andresult in ≤30% residual stenosis and no evidence of embolization or significantcomplications. Below the knee (BTK) group:

10. Target lesions involve arteries below the tibial plateau

11. Successful treatment of inflow vessel (from ipsilateral iliac to the target lesion)resulting in ≤30% residual stenosis with no evidence of embolization or significantcomplications

Exclusion Criteria:

1. Subject has a single target lesion that involves both ATK and BTK segments.

2. Subject not suitable for receiving endovascular procedures of lower limb arteries.

3. Prior planned major amputation in the target limb (i.e., above the ankle).

4. Subject with previous bypass surgery of target vessel.

5. History of any open surgical procedure within the past 30 days.

6. Planned vascular surgery procedure within the next 30 days after the ATK and/or BTKprocedure on the target limb. Note: The inflow vessels can be treated on the day of the procedure.

7. Subject has Oscar IFU listed contraindication (such as uncorrected bleedingdisorders, sepsis).

8. Subject under dialysis.

9. Subject currently enrolled in another investigational device, biologic, or drugtrial in which the primary endpoint has not yet been reached.

10. Subject lacking capacity to provide informed consent.

11. Subject under judicial protection, tutorship, or curatorship (for France only).